Category: Health Problems

Immunization with beneficial bacteria makes brain more stress resilient, study shows

Immunization with beneficial bacteria can have long-lasting anti-inflammatory effects on the brain, making it more resilient to the physical and behavioral effects of stress, according to new research by University of Colorado Boulder scientists. The findings, if replicated in clinical trials could ultimately lead to new probiotic-based immunizations to protect against posttraumatic stress disorder (PTSD)

Lab-grown neurons improve breathing in mice after spinal cord injury

Researchers from Drexel University College of Medicine and the University of Texas at Austin improved respiratory function in rodents with spinal cord injuries after successfully transplanting a special class of neural cells, called V2a interneurons. Their results, published this week in the Journal of Neurotrauma, indicate that these lab-grown cells have the potential to one

New lab technology could reveal treatments for muscle-wasting disease

Researchers from Queen Mary University of London have developed new cell-based technologies which could help improve understanding of the muscle-wasting disease Duchenne muscular dystrophy (DMD) and test potential drugs for the disease. DMD is a genetic disorder causing muscle degeneration and weakness, caused by an absence of the protein dystrophin. DMD usually affects only boys,

Major heart attacks are more deadly during colder months

Heart attacks are more likely to kill you in the winter than in the summer, according to new research presented at the British Cardiovascular Society Conference in Manchester today. Cardiologists at Leeds General Infirmary compared information from 4,056 people who received treatment for a heart attack in four separate years, and found the most severe

Diabetes results from a breakdown of epigenetic control

Diabetes affects more than 400 million individuals worldwide. In what is becoming a paradigm shift, researchers have begun to find that the disease may result in part through pancreatic beta cells losing their functional identity and shutting down their ability to release the blood sugar-lowering hormone, insulin. Researchers from the Max Planck Institute of Immunobiology

Stunting cell ‘antennae’ could make cancer drugs work again

Scientists have uncovered a completely new way to make cancers sensitive to treatment—by targeting antenna-like structures on cells. Their study found that drug-resistant cancer cells have more and longer antennae than those which are killed by treatment. Blocking the growth of antennae reactivated a range of cancer treatments that had stopped working, the team at

Major pancreatic cancer breakthrough

Clinical trial results presented today at a prestigious cancer meeting in Chicago show substantial increased survival rates for pancreatic cancer patients who received a four-drug chemotherapy combination known as mFOLFIRINOX after surgery. Pancreatic cancer is typically very aggressive, with only approximately eight per cent of people surviving beyond five years after diagnosis, even after surgery

Researchers engineer human bone marrow tissue

Researchers have developed an artificial tissue in which human blood stem cells remain functional for a prolonged period of time. Scientists from the University of Basel, University Hospital Basel, and ETH Zurich have reported their findings in the scientific journal PNAS. In the bone marrow, several billion blood cells are formed each day. This constant

Blood mutations could contaminate genetic analyses of tumors

Genetic mutations in blood cells that have made their way into tumors could be red herrings that mislead physicians looking for genetic changes in tumors that are helping to drive the cancer. This finding is significant because physicians could make misinformed treatment decisions. At the 2018 American Society of Clinical Oncology Annual Meeting this week,

Functional MRI reveals memory in sleeping toddlers

Our ability to remember past events develops rapidly in the first couple of years of life, but it’s not clear exactly how this happens. Researchers at the Center for Mind and Brain at the University of California, Davis have now been able to carry out functional MRI brain scans of sleeping toddlers, and show for

Researchers transform human blood cells into functional neurons

Human immune cells in blood can be converted directly into functional neurons in the laboratory in about three weeks with the addition of just four proteins, researchers at the Stanford University School of Medicine have found. The dramatic transformation does not require the cells to first enter a state called pluripotency but instead occurs through

Inflammatory signals in heart muscle cells linked to atrial fibrillation

Interfering with inflammatory signals produced by heart muscle cells might someday provide novel therapeutic strategies for atrial fibrillation, according to an international team of researchers who have published their findings in the journal Circulation. “Atrial fibrillation is the most common heart arrhythmia, and it is particularly observed in the elderly human population, which is growing

Preschool and school-age irritability predict reward-related brain function

Preschool irritability and concurrent irritability were uniquely associated with aberrant patterns of reward-related brain connectivity, highlighting the importance of developmental timing of irritability for brain function, finds a study published in the June 2018 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). “Irritability is one of the most frequent