Medications That Can Change the Color of Your Urine

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Medications that can turn urine orange

Isoniazid, an antibiotic used for the treatment of tuberculosis
Sulfasalazine, an anti-inflammatory used to treat rheumatoid arthritis and ulcerative colitis
Riboflavin (also known as vitamin B2), a vitamin included in many over-the-counter multivitamins

Medications that can turn urine brown

Metronidazole (Flagyl), an antibiotic used to treat bacterial vaginosis, C. diff diarrhea and other gastrointestinal infections
Nitrofurantoin (Macrobid), an antibiotic used to treat and prevent urinary tract infections
Acetaminophen (Tylenol), when overdosed

Medications that can turn urine blue or green

Amitriptyline (Amitril), a medication used to treat depression
Cimetidine (Tagamet), an acid blocker used for GERD (acid reflux) and heartburn symptoms
Indomethacin (Indocin), an anti-inflammatory used for the treatment of gout
Zaleplon (Sonata), an atypical benzodiazepine used as a sleep medication
Methocarbamol (Robaxin), a non-sedating muscle relaxant used for neck and back pain
Metoclopramide (Reglan), a medication used to treat nausea

Medications that can turn urine red

Warfarin (Coumadin), a blood thinner used in patients who have blood clots in the leg (i.e. deep vein thrombosis or DVT), atrial fibrillation, or a heart valve replacement
Rifampin, an antibiotic used to treat tuberculosis and may be used as a second agent to treat folks with MRSA (methicillin-resistant staph aureus) infections
Phenazopyridine (Azo, Pyridium), an over-the-counter drug used to treat pain related to urinary tract infections
Ibuprofen (Advil, Motrin), a nonsteroidal anti-inflammatory pain reliever

Many of the causes of abnormal urine color are harmless effects of medications and foods. However, a change in urine color can be a sign of an underlying medical condition. If you stop your medication and your strange urine color still doesn’t go away, see your doc.

Dr O.

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