Peptide-based vaccine fails to protect mice against SARS-CoV-2 despite T cell response

A recent study posted to the bioRxiv* preprint server observed that peptide-based vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) failed to protect mice against coronavirus disease 2019 (COVID-19), albeit eliciting T cell responses. Study: SARS-CoV-2 peptide vaccine elicits T-cell responses in mice but does not protect against infection or disease. Image Credit: neative/Shutterstock Background

Holter Monitor Changes Tied to Sustained Ventricular Arrhythmia Risk in Arrhythmogenic RV Cardiomyopathy

NEW YORK (Reuters Health) – In patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), changes in Holter exam findings after diagnosis were associated with the risk of sustained ventricular arrhythmias within a year, researchers say. “These findings…provide a new tool to dynamically monitor the risk of life-threatening cardiac arrhythmias in patients with ARVC during follow-up,” Dr.

Intensive treatment for patients with Crohn's disease found to be safe

Intensive treatment for patients with Crohn's disease showed no safety differences compared to the current standard of care, according to a trial published in the journal Gastroenterology. The findings offer some additional flexibility for treating patients with Crohn's disease, according to Stephen Hanauer, MD, the Clifford Joseph Barborka Professor of Medicine in the Division of

The ‘haves and have-nots’ of health information exchanges

Health information exchanges increase patient referrals among participating doctors, but that increase may be at the expense of physicians who aren’t part of the exchange, according to a new University at Buffalo School of Management study. Forthcoming in Management Science, the research analyzes the impact of health information exchanges on patient referral patterns. Referrals are

Sanofi, GSK to Seek Approval for COVID Vaccine Candidate

PARIS (Reuters) – French drugmaker Sanofi and its British partner GlaxoSmithKline are seeking regulatory approval for their COVID-19 vaccine to be used as a booster, as well as a standalone two-dose shot, after several setbacks. The companies said on Wednesday they intended to submit data to regulators from a late-stage trial of the vaccine, and

Exercising after a flu shot or COVID-19 vaccine may boost antibodies

A recent study suggests that exercising after getting a vaccine can boost antibodies. Iowa State University researchers found that light- to moderate-intensity exercise immediately after a flu or COVID-19 shot may increase protection against infection. Study participants produced more antibodies over the next 4 weeks post-vaccination, and they did not report increased side effects from

Mental health risk increases for COVID-19 survivors

A study tracking COVID-19 survivors found them more likely to develop mental health issues than other people over the year following diagnosis. The researchers saw an increased risk even for those whose COVID-19 was mild enough that they did not require hospitalization. Conditions the researchers investigated included anxiety, depression, opioid use, and cognitive decline. Researchers

Children and COVID: The Omicron Surge Has Become a Retreat

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The Omicron decline continued for a fourth consecutive week as new cases of COVID-19 in children fell by 42% from the week before, according to a report from the American Academy of Pediatrics and the Children’s Hospital Association. That 42% represents

Patients with rare skin cancer face 40% recurrence rate

Patients treated for Merkel cell carcinoma (MCC) face a five-year recurrence rate of 40%—markedly higher than the recurrence rates for melanoma and other skin cancers, according to research published today in JAMA Dermatology. Additionally, in the study cohort of more than 600 patients, 95% of MCC recurrences happened in the first three years, suggesting that