Ketamine's long-lasting antidepressant effects unveiled in new study

In a recent study published in the journal Nature, researchers investigate whether persistent blocking of N-methyl-D-aspartate receptor (NMDAR) and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of an NMDAR agonist, ketamine. Study: Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb. Image Credit: Pavlova Yuliia /

Adult ADHD Linked to a Twofold Increased Risk for Dementia

TOPLINE: Adult attention deficit hyperactivity disorder (ADHD) is associated with a more than twofold increased risk for incident dementia, a new nationwide cohort study shows. However, investigators found no increased dementia risk in adults with ADHD treated with psychostimulant medications, suggesting these medications may reduce this risk. METHODOLOGY: Investigators based their findings on the medical

Older adults from distressed communities attend less cardiac rehab after heart procedures, study finds

Older adults who live in disadvantaged communities are less likely to attend cardiac rehabilitation after common heart procedures, a Michigan Medicine-led study finds. The study aimed to calculate how many Medicare beneficiaries attended cardiac rehabilitation, a medically supervised program exercise and education program, after coronary revascularization between mid-2016 and 2018. Patient communities were categorized using

Do overweight individuals exhibit reduced cardiopulmonary fitness after recovering from COVID-19?

In a recent study published in Nature’s Scientific Reports, a team of scientists investigated factors such as cardiopulmonary fitness, body composition, and long-term symptoms associated with coronavirus disease 2019 (COVID-19) sequelae in individuals who had recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Study: Body composition and cardiorespiratory fitness of overweight COVID-19 survivors in

Sotorasib + panitumumab beneficial for chemorefractory metastatic CRC

For patients with chemorefractory metastatic colorectal cancer, the KRAS G12C inhibitor sotorasib in combination with the epidermal growth factor receptor inhibitor panitumumab results in longer progression-free survival than standard treatment, according to a study published online Oct. 22 in the New England Journal of Medicine. The research was published to coincide with the annual meeting

Does SARS-CoV-2 infection have urological effects?

Research published in the Journal of Internal Medicine indicates that SARS-CoV-2 infection may worsen lower urinary tract symptoms (LUTS) in men. The study included 17,986 men receiving medication for LUTS within the public health care system of Hong Kong in 2021–2022, half of whom had SARS-CoV-2 infection. The group with SARS-CoV-2 had significantly higher rates

Bagged, precut onions tied to salmonella illnesses in 22 states

Federal regulators are investigating a salmonella outbreak linked to packaged, diced onions that has sickened at least 73 people across 22 states. Fifteen of the illnesses were so bad that people required hospitalization. Gills Onions has already issued a recall for the products, which include diced yellow onions, diced onions and celery, diced mirepoix (onions,

Highest risk patients with clear-cell renal cell carcinoma benefit from adjuvant everolimus: Clinical trial

A secondary analysis from the SWOG S0931 EVEREST trial has found that in the subgroup of patients with clear-cell renal cell carcinoma (RCC) who were at very-high risk of recurrence, those who were treated with everolimus after surgery had a statistically significant improvement in recurrence-free survival compared to patients getting placebo after surgery. The results

AI and 10 seconds of voice can screen for diabetes, new study reveals

Determining whether a person is diabetic could be as easy as having them speak a few sentences into their smartphone, according to a groundbreaking study from Klick Labs that combines voice technology with artificial intelligence in a major step forward in diabetes detection. The new study, published in Mayo Clinic Proceedings: Digital Health, outlines how

New molecule to fight against transthyretin amyloidosis

Researchers from IBB-UAB have developed a second-generation molecule that significantly improves the stabilization and inhibition of the aggregation of proteins involved in Transthyretin Amyloidosis (ATTR), a group of minority degenerative diseases. The new molecule, called PITB (Pharmacokinetically Improved TTR Binder), is the result of a series of studies aimed at improving both the activity and

Study challenges link between low birth weight and childhood neurodevelopmental issues

Several epidemiological studies have suggested a link between being born too small and abnormal neurodevelopment in childhood and later life. However, there is little evidence that these factors are causally related to a hostile intrauterine environment. A new study in JAMA Psychiatry discusses this topic in greater depth. Study: Intrauterine growth and offspring neurodevelopmental traits: a