Tag: Amyotrophic Lateral Sclerosis

Blue-collar workers, particularly carpenters and construction workers, have a significantly increased risk for amyotrophic lateral sclerosis (ALS) compared with white-collar workers, new research shows. Investigators found manual laborers had a twofold increased risk for the fatal neurodegenerative disease, possibly because of the intense or sustained physical effort these jobs require. “Our study provides evidence that

“Symptoms, then, are in reality nothing but a cry from suffering organs” – Jean-Martin Charcot Nearly 130 years after his death, Jean-Martin Charcot’s name still resonates with modern neurologists. The famed 19th century French physician made myriad enduring contributions to the field. His eponymous foot condition might be his best known. He also delved into

Increased glucose, transformed into energy, could give people with amyotrophic lateral sclerosis, or ALS, improved mobility and a longer life, according to new findings by a University of Arizona-led research team. Physicians have long known that people with ALS experience changes in their metabolism that often lead to rapid weight loss in a process called

St. Jude Children’s Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. The research suggests possible new approaches to diagnosis and treatment of the lethal disorder. The findings appear online today in the journal Molecular Cell. About 35 percent of ALS cases

Binge drinking in adolescence has been shown to have lasting effects on the wiring of the brain and is associated with increased risk for psychological problems and alcohol use disorder later in life. Now, researchers at the University of Illinois at Chicago Center for Alcohol Research in Epigenetics have shown that some of these lasting

Patients with ALS frequently have a string of repeated DNA code in the cells of their brain, carrying hundreds to thousands of copies within the gene C9orf72. New research looks at what triggers these repeated sequences to eventually produce the toxic proteins that are associated with ALS, frontotemporal dementia, and other neurodegenerative diseases in patients

Virginia Tech Carilion Research Institute scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis — also known as ALS or Lou Gehrig’s disease — also attack sensory neurons. The discovery in today’s (Thursday, Nov. 8) Scientific Reports indicates that studying sensory neurons

NIH-funded researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of the disease caused