Tag: Cholesterol

New drug could help those with tough-to-treat cholesterol

People whose high cholesterol is resistant to treatment with statin drugs may soon have a new treatment option. This new class of drugs helps block synthesis of artery-clogging cholesterol, researchers explained. The drugs target an enzyme called ATP citrate lyase (ACL), part of the production pathway for “bad” LDL cholesterol in the body. In the

Predictors that determine toxic fats in the liver

Accumulation of fat in the liver, known as fatty liver disease, is experienced by over 5.5 million Australians, including more than 40% of all adults over the age of 50. Fatty liver develops from a combination of both genetic and environmental causes, which influence the age of onset and severity of the disease. Experts are

Drug shows promise to treat diet-induced osteoarthritis

QUT scientists have found that a drug derived from omega-3 fatty acids can reduce osteoarthritis inflammation that’s been caused by a high-fat diet. The study, published in Nature journal Scientific Reports, is among the first to investigate resolvin D1 (RvD1), which has reported anti-inflammatory properties, as a possible treatment for diet-associated osteoarthritis, which affects knees,

Technique boosts omega 3 fatty acid levels in brain 100 fold

Getting enough of the omega 3 fatty acids DHA and EPA into the brain to study their effects on conditions such as Alzheimer’s and depression — which they have been shown to help — is no easy task. While supplements containing these fatty acids exist, there is scant evidence showing that these supplements actually increase

AHA: guidelines stress healthy lifestyle for lowering cholesterol

(HealthDay)—A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course, according to a guideline published online Nov. 14 in Circulation to coincide with the annual meeting of the American Heart Association, held from Nov. 10 to 12 in Chicago. Scott M. Grundy, M.D., Ph.D., from the University of

Failing heart cells trigger self-protection mechanism: Stress transforms an important structural protein into a gene regulator that protects against heart failure

An unexpected finding that links a structural heart protein to gene regulation following heart stress suggests potential new avenues for developing heart failure therapies. The work led by University of Iowa heart researcher Long-Sheng Song, MD, focuses on a protein called junctophilin-2 (JP2). Previous work from Song’s lab has shown that JP2 is a structural

Updated cholesterol guidelines offer more personalized risk assessment, additional treatment options

More personalized risk assessments and new cholesterol-lowering drug options for people at the highest risk for cardiovascular disease (CVD) are among the key recommendations in the 2018 cholesterol guidelines from the American Heart Association (AHA) and the American College of Cardiology (ACC). The guidelines were presented today at the Association’s 2018 Scientific Sessions conference in

Fasting before a cholesterol test: What to do and what to expect

A cholesterol test measures the amount of cholesterol and triglycerides in a person’s blood. Cholesterol is a fat-like material that is present in all of the body’s cells. The body needs some cholesterol to help produce vitamin D, hormones, and enzymes that aid digestion. A cholesterol test, also known as a lipids panel, measures several

Higher BMI may lower your mental, physical health

The study explored the aspects of physical health such as body weight, heart health and blood pressure to see whether a wide range of individuals with poorer physical health went on to be less happy and less satisfied with their lives or not. There is a growing need to prevent obesity as a new study

Caspase-2 enzyme inhibitor shows promise for ameliorating fatty liver disease: Researchers identify enzyme as responsible for onset and progression of fatty liver disease in mice and human clinical specimens

Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to

How damaging immune cells develop during tuberculosis

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues. Foam cells are a type of white blood cell, known as

Rethinking a healthy diet from a global perspective: Presented at a hotline session at the European Society of Cardiology Congress

Recommendations for a high quality diet to avoid cardiovascular disease were developed in high-income countries two to three decades ago. They don’t consider other parts of the world or how diets have changed. Now scientists of the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences are using research from several large