Tag: Combination

Glioblastomas are the most common and most aggressive brain tumors. Their survival rate has barely increased over the last 50 years, indicating an urgent need to develop new therapeutic strategies. In a paper published this week in the journal Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, the team led by

Researchers from the Mitochondrial Medicine Frontier Program at Children’s Hospital of Philadelphia (CHOP) have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders. This preclinical research paves the way to develop more tailored treatment options for patients with inherited mitochondrial disease and acquired energy disorders. The findings emphasize

A clinical trial led by Mount Sinai researchers has showed for the first time that combining chemotherapy and immunotherapy can slow down metastatic bladder cancer. The trial also showed that immunotherapy alone may be an option for a subset of patients with metastatic bladder cancer if their tumor expresses a high level of a protein

Today, Cochrane publishes a new Rapid Review looking at quarantine during the COVID-19 pandemic. The review summarizes evidence available from modelling studies that show how quarantining affects the spread of COVID-19. The studies included in the review consistently conclude that quarantine can play a role in controlling the spread of coronavirus SARS-CoV-2. While early implementation

An artificial intelligence (AI) tool—trained on roughly a million screening mammography images—identified breast cancer with approximately 90 percent accuracy when combined with analysis by radiologists, a new study finds. Led by researchers from NYU School of Medicine and the NYU Center for Data Science, the study examined the ability of a type of AI, a

In continuing efforts to find novel ways to kill cancer cells, researchers at the University of Maryland School of Medicine (UMSOM) have identified a new pathway that leads to the destruction of cancer cells. The new finding, published this week in the journal PNAS, could pave the way for the broader use of a class

A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed treatment for heart failure, according to new research part-funded by the British Heart Foundation (BHF) and published in Nature Biotechnology. Researchers have found that, by transplanting an area of damaged tissue with a combination of both heart

A combination of two drugs, which prompt the body’s immune system to identify and kill cancer cells, is a safe treatment for patients with advanced non-small cell lung cancer and has shown some signs of efficacy. Results from a phase I/II clinical trial in 25 patients, presented at the 30th EORTC-NCI-AACR Symposium on Molecular Targets

Think of the protein BH3 like a finger that turns off a cancer cell survival switch. The problem is that most cancer cells have found ways to remove this “finger—commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion. Now think of Bcl-2 as the switch itself. When

A new clinical trial at Emory University and 45 other sites around the U.S. will test a combination of vitamins and steroids in patients diagnosed with sepsis. Sepsis is caused by the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure and death. According to sepsis researchers, sepsis can

(HealthDay)—The risk of death from dangerously low blood sugar is much higher among seniors who have both diabetes and dementia than those with diabetes alone, a new study finds. Researchers analyzed data from nearly 20,000 people aged 65 and older with type 1 or type 2 diabetes who were followed for up to five years

Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy (BKI) released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer. The study suggested a genetic subset of prostate cancer may benefit from this form of immunotherapy. The study

People who are prescribed a combination pill to manage their high blood pressure are more likely to take their medicine as instructed and have better health outcomes than those who take the same medications prescribed as separate pills, according to a new study published today. “Using single-pill combinations rather than multiple pills may represent a

Gender can have an influence on psychotherapy. This is backed up by the latest analysis and long-term research carried out by the director of the Psychotherapy and Counselling Science BA-degree programme at Karl Landsteiner University of Health Sciences in Krems (KL Krems). The results show that gender identity affects the emotions of both patients and

The combination of taselisib and fulvestrant has shown to slow the growth of cancer in post-menopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2) negative, PIK3CA-mutant, inoperable, locally advanced or metastatic breast cancer. Researchers from Memorial Sloan Kettering Cancer Center (MSK) presented this data, from the SANDPIPER trial, in a press conference

Immunotherapies are treatments that stimulate a patient’s immune cells to attack tumors. They can be very effective in melanoma—a common and aggressive form of skin tumor—but nonetheless fail in the majority of patients. To address this, researchers are trying to identify the factors that enable successful immunotherapy, as well as those that may limit it.

In collaboration with a number of American colleagues, researchers from Uppsala University have found an Achilles’ heel for the most common form of malignant child brain tumours. By combining two kinds of medicines, it is possible to simultaneously attack the cancer cell’s division and its reinforcement system, which is necessary in order for treatment to