Tag: disease

Reversing polycystic kidney disease

Hereditary and relatively common, polycystic kidney disease (PKD) has long been thought to be progressive and irreversible, condemning its sufferers to a long, slow and often painful decline as fluid filled cysts develop in the kidneys, grow and eventually rob the organs of their function. Once their kidneys fail, PKD patients often require dialysis several

Study finds WeChat program helps recovery of heart disease patients

Patients recovering from life-threatening coronary heart disease who received rehabilitation through WeChat experienced a better recovery than those having standard care, new Curtin University-led research has found. The research, published in The Lancet Digital Health, recruited 312 patients with coronary heart disease from a hospital in Shanghai, China, and measured the effectiveness of a smartphone-based

FODMAPs diet relieves symptoms of inflammatory bowel disease

New research from King’s College London has found that a diet low in fermented carbohydrates has improved certain gut symptoms and improved health-related quality of life for sufferers of inflammatory bowel disease (IBD). In a paper published today in Gastroenterology a team of researchers carried out a trial of a diet low in fermentable oligosaccharides,

Researchers identify rare inherited immune disease

When a 9-year-old girl with anemia, breathing problems, and recurrent infections sought help for her mysterious ailments, Yale researchers and their collaborators at the National Institutes of Health sequenced her genes to pinpoint a cause. What they discovered was not only a new disease but unexpected new roles for a gene that affects the immune

Solving long-sought protein structure opens new avenues for treating disease

Scientists at Sanford Burnham Prebys have identified the long-sought structure of an essential blood protein: vitronectin. Knowing the protein’s structure—an advance that enables rational drug design—could lead to medicines that kill multi-drug-resistant bacteria, halt cancer metastasis, treat age-related macular degeneration (AMD) and more. The study was published in Science Advances.  “For decades, scientists have speculated

Artificial intelligence approaches may improve diagnostics of kidney disease

Two new studies reveal that modern machine learning—a branch of artificial intelligence in which systems learn from data, identify patterns, and make decisions—may augment traditional diagnostics of kidney disease. The findings appear in an upcoming issue of JASN. Pathologists often classify various kidney diseases on the basis of visual assessments of biopsies from patients’ kidneys;

Possible treatment on the horizon for severe dengue disease

Researchers led by Duke-NUS Medical School have discovered that tryptase, an enzyme in human cells that acts like scissors to cut up nearby proteins, is responsible for blood vessel leakage in severe dengue hemorrhagic fever. The finding suggests a possible new treatment strategy using the tryptase inhibitor, nafamostat mesylate, for severe dengue disease—a potentially fatal

Childhood cancer survivors at elevated risk of heart disease

Survivors of childhood cancer have a higher risk of developing a range of heart disease due to cancer therapy, according to new research published in the American Heart Association’s journal Circulation. Most studies of this survivor group have focused on heart failure related to anthracyclines, a class of chemotherapy medications used to treat many types

New vaccine targets killer disease tuberculosis

There is only one existing vaccine for TB and it is not effective in adults. Researchers at the Centenary Institute and University of Sydney will next test their new vaccine in clinical trials with humans. Australian medical researchers from the Centenary Institute and the University of Sydney have successfully developed and tested on mice a

An omega-6 fatty acid could help in fight against heart disease

An omega-6 polyunsaturated fatty acid has the potential to help fight heart disease, finds a new study by researchers at Cardiff University, in collaboration with Ben-Gurion University of the Negev. With funding from the British Heart Foundation, the team found that dihomo-gamma-linolenic acid (DGLA), an omega-6 polyunsaturated fatty acid, could halt the progression of atherosclerosis—one

Alzheimer’s drug trial targets by-product of gum disease

The pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer’s drug that targets toxic substances released by P. gingivalis, a bacteria linked to gum disease. In a poster presented at the Alzheimer’s Association International Conference today (Wednesday, July 17), researchers provided an overview of the development of the drug, known as COR388, and

Alzheimer’s disease: Sex affects tau accumulation in the brain

The strongest genetic risk factor for Alzheimer’s disease is the apolipoprotein E type 4 allele (ApoE ε4). Research presented by Manish Paranjpe at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) used positron emission tomography (PET) to show that women who are ApoE ε4 carriers and already experiencing mild