Tag: Diseases and Conditions

Erythropoietin (EPO) helps to protect and repair vulnerable brains though it remains a mystery how the anemia drug does so. Genetic analyses conducted by a multi-institutional research team finds that EPO may work its neuroprotective magic by modifying genes essential for regulating growth and development of nervous tissue as well as genes that respond to

Researchers at Tufts University have elucidated a mechanism by which the “good” bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study, now available in the journal Cell Reports, identified two key

A letter from three University of Chicago researchers in this week’s New England Journal of Medicine updates a 47-year-old series of reports on the risks of exposure during pregnancy to a supplement, diethylstilbestrol (DES), that was once widely used but since 1971 has been linked to a rare cancer: clear-cell adenocarcinoma of the vagina and

A new JBMR Plus review examines the negative impacts of weight loss surgery on bone health. The review of published studies notes that weight loss surgery can cause declines in bone mass and strength, and it is linked with an increased risk of bone fractures. Skeletal changes after surgery appear early and continue even after

Peptides are short chains of amino acids that can bind to proteins and change their function. They show high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occurring peptides such as insulin, oxytocin, somatostatin and the antibiotics vancomycin or polymyxin

Alzheimer’s disease currently affects more than 5.5 million Americans and is one of the costliest diseases to treat, according to the Alzheimer’s Association. Characterized by a buildup of plaque in the brain, few animal models exist that researchers could use to study this devastating disorder. Now, a team of researchers from the University of Missouri,

A collaborative team of researchers at McLean Hospital, a Harvard Medical School affiliate, and Oxford University has found that elevated levels of certain types of lipids (fat molecules) in the brain may be an early sign of Parkinson’s disease (PD). This finding could have significant implications for identifying patients who may be at risk for

About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect — they induce the bone loss called osteoporosis, causing an estimated yearly bone fracture rate of 5 percent. An alternative treatment option now appears promising, according to results of

Researchers at the University of Birmingham have developed a contact lens that may help people with colour blindness simply by using a low cost dye, according to research published today (26 April 2018) in the journal Advanced Healthcare Materials. Colour blindness — or colour vision deficiency (CVD) — is an inherited genetic ocular disorder where

Researchers from UCLA and several other institutions found surgeries performed by older surgeons — age 50 and up — have lower patient mortality rates than those performed by younger surgeons, and that patient mortality rates do not differ significantly based on whether the surgeon is male or female. Broken down by age group and adjusting

Occurrence of Rift Valley Fever (RVF) has often been linked with El Niño rainfall. To curb future outbreaks of RVF, M. Kariuki Njenga and colleagues carried out enhanced syndromic surveillance of 22 high-risk RVF Kenyan counties to collect data on RVF-associated syndromes and risk factors in livestock from November 2015 through February 2016. Their research,

Boston University researchers, Thomas Kepler, professor of microbiology; Stephanie Pavlovich, an MD/PhD student; and Elke Mühlberger, director, Biomolecule Production Core, National Emerging Infectious Diseases Laboratories (NEIDL); in collaboration with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) and the Centers for Disease Control and Prevention’s (CDC) Viral Special Pathogens Branch, today released

Many bacteria are equipped with a flagellum, a helical propeller that allows bacteria to travel. The flagellum is assembled in a highly organized manner involving the stepwise addition of each of its internal parts. However, there are many open questions as to how this orderly construction is achieved. In a study published in Science Advances,

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. The outcomes of the study, “Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study,” will be a

Washington State University researchers have developed a low-cost, portable laboratory on a phone that works nearly as well as clinical laboratories to detect common viral and bacterial infections. The work could lead to faster and lower-cost lab results for fast-moving viral and bacterial epidemics, especially in rural or lower-resource regions where laboratory equipment and medical

According to new research, obese women with polycystic ovary syndrome (PCOS) may be able to improve their health outlook with a particularly enjoyable form of therapy: regular sessions in a hot tub. The research found that soaking in a hot tub several times per week for two months results in improved measures of cardiovascular health,

A new study from McMaster and York universities has found that poor muscle health may be a complication of Type 1 diabetes, even among active twenty-somethings. The research team analyzed muscle biopsies of young adults with and without Type 1 diabetes who exceed Diabetes Canada’s recommended weekly levels for physical activity. The researchers found structural

A male’s total testosterone level may be linked to more than just sexual health and muscle mass preservation, a new study finds. Low amounts of the hormone could also be associated with chronic disease, even among men 40 years of age and younger. “If we look at data for men from a population level, it

New research indicates that belimumab, a monoclonal antibody therapy that targets a component of the immune system, provides considerable benefits to patients with systemic lupus erythematosus (SLE), a predominately female, chronic inflammatory disease that can affect virtually any organ. The Arthritis & Rheumatology findings are encouraging because lupus is among the leading causes of death

A team of scientists, led by academics from King’s College London and Erasmus MC University Medical Center Rotterdam, have discovered 124 genes that play a major role in determining human hair colour variation. The discovery sheds new light on our understanding of the genetic complexity underpinning variations in human pigmentation, and could advance our knowledge