Tag: drugs

Cytotoxic drugs can increase cancer cell resistance

Cancer cells sometimes develop resistance to the cytotoxic drugs used in chemotherapy. Figuring out why the treatment isn’t working and why it may even defeat its own purpose is therefore important to understand. “We haven’t understood very much about how this resistance to chemotherapy develops and even less about how the microenvironment in cancer can

WEHI collaborates with Boehringer Ingelheim to develop novel anti-cancer therapeutics

WEHI has partnered with Boehringer Ingelheim, a leading research-driven pharmaceutical company, in a collaboration to discover and develop anti-cancer therapeutics using a promising new technology called targeted protein degradation. The partnership builds on more than 25 years of pioneering discoveries at WEHI, into a family of proteins known as the inhibitor of apoptosis proteins (IAPs)

New evidence supports ivermectin use in children weighing less than fifteen kilograms

Millions of children weighing less than 15kg are currently denied access to Ivermectin treatment due to insufficient safety data being available to support a change to the current label indication. The WorldWide Antimalarial Resistance Network (WWARN)'s new meta-analysis published today provides evidence that supports removing this barrier and improving treatment equity. A systematic review and

Counterfeit Medications

A counterfeit medication or drug is defined as a pharmaceutical product that is produced and sold with the intention to deceive the consumer about the origin, authenticity or efficacy of the product. This has the potential to be dangerous for consumers as the formulation may contain unusual ingredients or quantities of the ingredients, which can

Causes of Nocturnal Awakenings

Insomnia is a very common sleep disorder, and presents in various types. However, sleep maintenance insomnia (SMI) is the most frequent complaint. Both the cause of awakening and the difficulty in returning to sleep are important in precipitating episodes of nocturnal sleep disturbances. Research seems to suggest that hyperarousal states, personality traits, and physiologically determined

Are the side-effects of new cancer 'wonder drugs' worth the risk?

Are the potentially crippling side-effects of new cancer ‘wonder drugs’ worth the risk? Patients with otherwise untreatable tumours benefiting from immunotherapy  The treatment costs around £100,000 per patient per year, and has side-effects One in ten patients given immunotherapy for cancer suffer rheumatoid arthritis Surviving cancer against the odds can give patients a new lease

Drugs bill warning over US/UK trade deal

The NHS would spend billions of pounds more on drugs if it had to pay US prices following a US/UK trade deal. According to a new study by researchers at Brigham and Women’s Hospital in Boston, Harvard Medical School, and the University of Oxford, published by the Journal of the Royal Society of Medicine, NHS

Antihistamines and similar drugs could slow down Huntington’s disease

Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington’s disease in a new study published today in eLife. The research in mice indicates that targeting the histamine H3 receptor (H3R) – a well-established drug target for other conditions such as hay fever—could help to prevent imbalances in dopamine signaling that lead

Certain combinations of cardiovascular drugs may reduce dementia risk

Specific combinations of statins and antihypertensives may also reduce risk for Alzheimer’s disease, according to a new USC study of nearly 700,000 Medicare beneficiaries. The findings suggest that treatments already in use for blood pressure and cholesterol control could reduce the number of people with Alzheimer’s and related dementias, researchers said. The study was published