Tag: gene

‘Cannabis addiction’ gene has been discovered by scientists

‘Cannabis addiction gene’ that could make people more likely to abuse the drug is discovered by scientists in a ‘really important’ breakthrough Gene CHRNA2 regulates a ‘nicotine receptor’ in the brain, scientists have said  Low levels of this receptor has been linked to an increased of marijuana abuse Discovery could help medics treat and even

Researchers uncover new sarcoma gene

A team of WA researchers has uncovered new genes that could play an important role in the development of sarcoma, a group of rare bone, muscle and connective tissue cancers. The study, undertaken by Ph.D. student Rachel Jones and led by Associate Professor Evan Ingley from the Harry Perkins Institute of Medical Research and Murdoch

A deep-dive into the impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology. People with rheumatoid arthritis often receive medications that target and inhibit Tumor-Necrosis Factor (TNF), a

Gene editing for recessive dystrophic epidermolysis bullosa: A little bit closer to clinical applications

A group of researchers from the Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (Biomedical Research Networking Centre on Rare Diseases), Universidad Carlos III de Madrid (UC3M), the Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) (Research Center for Energy, Environmental and Technology), and the Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)

Gene Test Predicts Risk of 5 Common Diseases

TUESDAY, Aug. 14, 2018 — A new type of genetic analysis could identify millions of Americans at high risk for five serious and common diseases, researchers report. The diseases include coronary artery disease, the heart rhythm disorder atrial fibrillation, type 2 diabetes, inflammatory bowel disease and breast cancer. Researchers tested and validated the genetic risk

Parkinson’s gene affects more people than previously thought

Almost 1 million people in the United States and nearly 10 million people across the world live with Parkinson’s disease. According to the National Institutes of Health (NIH), 15 percent of those living with Parkinson’s have a hereditary form of the disease. Such hereditary forms of the condition are often down to mutations in several

Researchers identify new arthritis severity gene

A new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicine at Mount Sinai. The discovery could provide a new pathway for treatment and a way to measure the prognosis of patients diagnosed with the autoimmune condition. Through a series of experiments—on synovial

With gene editing, researchers cure blood disorder in fetal mice

With the combined efforts of three Yale laboratories, researchers conducted the first demonstration of site-specific gene editing in a fetus, correcting a mutation that causes a severe form of anemia. The technique, described in a paper published June 26 in Nature Communications, involves an intravenous injection of nanoparticles carrying a combination of donor DNA and

RB1 gene mutations underlie clinical resistance to CDK 4/6 inhibitor breast cancer therapy

A multi-institutional research team has identified what may be a novel mechanism underlying acquired resistance to CDK 4/6 inhibitor treatment for breast cancer. In their report published in the Annals of Oncology, the team—led by investigators at Massachusetts General Hospital (MGH), Institute Gustave Roussy in Paris, and Texas Oncology-Baylor Sammons Cancer Center/U.S. Oncology in Dallas—reports