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Zooming into cilia sheds light into blinding diseases

A new study published today by researchers from Baylor College of Medicine and UT Health’s McGovern Medical School in the Proceedings of the National Academy of Sciences reveals an unprecedented close-up view of cilia linked to blindness. Cilia are short hair-like structures found on the surface of certain cells. They are particularly important in vision

Cycles of reward: New insight into ADHD treatment

Attention-deficit hyperactivity disorder (ADHD) is a widespread condition with complex underlying causes. A stimulant drug called methylphenidate is a common ADHD treatment that impacts the brain’s levels of dopamine, a neurotransmitter involved in systems of reward; however, methylphenidate has a potential for abuse, and its therapeutic effects are poorly understood. To explore methylphenidate’s varied interactions

Direct relationship between depression and inflammation called into question

Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine . Over the past few decades, there have been many studies into the relationship between depression and inflammation in the

First lung map uncovers new insights into asthma

For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. The research from the Wellcome Sanger Institute, University Medical Center Groningen, Open Targets, GSK and collaborators revealed the identity of each cell type, creating the first draft Human Cell Atlas of the

New insights into treatment targets for men with advanced prostate cancers

A study published recently in the Journal of Clinical Oncology Precision Oncology, an American Society of Clinical Oncology (ASCO) journal, outlines findings from the largest-ever prospective genomic analysis of advanced prostate cancer tumors. Using comprehensive genomic profiling (CGP) to analyze thousands of tumor samples from men with advanced prostate cancers, the researchers identified that 57

A deep-dive into the impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology. People with rheumatoid arthritis often receive medications that target and inhibit Tumor-Necrosis Factor (TNF), a

New insights into the development and therapy of cancer

Oncologists at the University and University Hospital in Tübingen have discovered a new protein variant that plays an important role in the development and therapy response of cancer. For physicians, this discovery opens up the opportunity for new options in the diagnosis and therapy of cancer. The results of the study were published on Tuesday,

Varicose veins unlikely to develop into blood clots

Similar to leaky pipes, veins, as they return blood to the heart, sometimes fail to close completely. They stretch out and subsequently leak near the surface of the skin, creating spider or varicose veins that may cause discomfort. Dr. Tanya Flohr, a vascular surgeon at Penn State Heart and Vascular Institute, said the majority of

‘Mind-Reading’ AI Turns Thoughts Into Spoken Words

TUESDAY, Jan. 29, 2019 — In a breakthrough straight out of the world of science fiction, a team of researchers has used artificial intelligence (AI) to turn brain signals into computer-generated speech. The feat was accomplished with the assistance of five epilepsy patients. All had been outfitted with various types of brain electrodes as part