Tag: lung

Phase 1 study shows novel KRAS inhibitor well tolerated by patients with adenocarcinoma and non-small cell lung cancer

A clinical trial testing the toxicity of a KRAS inhibitor demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation, according to research presented today at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study of

Innovative patient-centred lung clinic reduces suffering along with costs

A unique clinic for patients with terminal lung disease is leading to dramatic reductions in hospital deaths, better symptom management and lower costs for the health-care system. The multidisciplinary team at Alberta Health Services’ Kaye Edmonton Interstitial Lung Disease Clinic delivers palliative care and encourages treatment at home for patients with idiopathic pulmonary fibrosis (IPF).

First lung map uncovers new insights into asthma

For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. The research from the Wellcome Sanger Institute, University Medical Center Groningen, Open Targets, GSK and collaborators revealed the identity of each cell type, creating the first draft Human Cell Atlas of the

Trial remedies racial disparities in treatment for early-stage lung and breast cancer patients

Results from a study published in the Journal of the National Medical Association show that a pragmatic system-based intervention within cancer treatment centers can nearly eliminate existing disparities in treatment and outcomes for black patients with early-stage lung and breast cancer. The treatment completion rates before this intervention were 87.3 percent for white patients versus

Treatment to a T? Taking a ‘BiTE’ out of lung cancer

Immune cells called T cells are key components in the fight against cancer. However, they sometimes struggle to recognize cancerous cells or to launch an appropriate response against them. T cell activity can be tweaked to improve anticancer effects using cancer immunotherapy, but this is only effective for a subset of patients, who are difficult

Multichannel bioreactor for lung regeneration analysis

New strides are being made toward the ex vivo growth of human lungs. In a new article published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, researchers report the development of a high-throughput, automated, multichannel lung bioreactor that allows parallel culture of up to five human cell-populated isolated rat lung scaffolds.

Woman, 68, receives her lung donor’s peanut allergy

Woman, 68, who received a lung transplant develops her donor’s peanut allergy in ‘very rare’ phenomenon The unnamed patient, from San Diego, had never had a reaction to nuts before When doctors heard a sandwich triggered her symptoms they were suspicious Nut allergies are only believed to have been passed on four or five times

Potential therapeutic target for lung fibrosis identified

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina (MUSC) report that they have identified a potential therapeutic target for lung fibrosis or scarring. They showed in a preclinical model that the protein promotes fibrosis by turning on profibrotic genes and increasing levels of profibrotic factors, including

Lung transplant patients face elevated lung cancer risk

In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. This was a large registry-linkage study that utilized matched transplant and cancer registry data from 17 US states/regions, including approximately 50 percent of US transplant recipients from 1987-2012. Researchers

Team spots clue to rare lung and kidney diseases

Pulmonary-renal syndrome (PRS) refers to a group of rare but potentially fatal conditions that nearly always are caused by a misguided attack by the body’s immune system on the lungs and kidneys. Coughing up blood and blood in the urine are telltale signs. Treatment with corticosteroids and immunosuppressant drugs can be effective if begun before

Most patients with cystic fibrosis may receive insufficient antibiotics to fight lung infections

The majority of patients with cystic fibrosis may not achieve blood concentrations of antibiotics sufficiently high enough to effectively fight bacteria responsible for pulmonary exacerbations, leading to worsening pulmonary function, indicates a study led by researchers at Children’s National Health System. Additionally, the study findings show that it’s impossible to predict solely from dosing regimens

Childhood risk profiles affect middle-age lung function

(HealthDay)—Profiles of childhood respiratory risk factors predict middle-age lung function levels and chronic obstructive pulmonary disease (COPD) risk, according to a study published in the September issue of the Annals of the American Thoracic Society. Dinh S. Bui, from the University of Melbourne in Australia, and colleagues assessed 11 childhood risk factor profiles (documented at