Tag: melanoma

Researchers discover therapeutic target of melanoma

Researchers have identified a biomarker and a possible new therapy for melanoma. Microphthalmia-associated transcription factor (MITF) is a protein that plays a pivotal role in the maintenance of the melanocyte (cells that make melanin) lineage, differentiation of normal and malignant melanocytes and the survival of melanoma cells. “We have now detected the first useful chemical

Toward an ‘ultra-personalized’ therapy for melanoma

With new immunotherapy treatments for melanoma, recovery rates have risen dramatically, in some cases to around 50%. But they could be much higher: A new study led by researchers at the Weizmann Institute of Science showed, in lab dishes and animal studies, that a highly personalized approach could help the immune cells improve their abilities

Scientists test new cancer vaccine against melanoma

An experimental cancer vaccine that boosts the immune system’s ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumors, scientists reported recently in the Proceedings of the National Academy of Sciences. The researchers demonstrated that adding a molecule called Diprovocim to a vaccine can draw cancer-fighting cells to tumor

Glycans at the ‘I’ of the storm in humoral immunity and melanoma progression

Two new studies have unveiled how a peculiar molecule impacts how antibody-producing cells develop and function as well as how normal melanocytes progress to melanoma malignancy. “These findings on fundamental immunology and melanoma development originate from totally different areas of research, though have intersected at the bench,” said Charles Dimitroff, Ph.D., of the Department of

Researchers map DNA damage links to onset of skin cancer, melanoma

A critical link in mapping recurrent mutations of melanoma—the most serious form of skin cancer in humans—has been discovered by researchers at Washington State University School of Molecular Biosciences, in collaboration with researchers at Georgia State University. In a paper published July 6 in Nature Communications, researchers established that DNA binding by a specific set

New guidelines may slightly increase reliability, accuracy of melanoma diagnoses

In a new study, researchers have developed updated guidelines for classifying a serious form of skin cancer called invasive melanoma. The American Joint Committee on Cancer, an organization that provides information on “cancer staging,” or the severity of individual cases of cancer, recently updated its guidelines for melanoma. The researchers found that when pathologists used