Tag: mouse

Incorporating genetic diversity into a mouse model of Alzheimer’s disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a study funded by the National Institute on Aging (NIA), part of the National Institutes of Health. The study also suggests that adding genetic diversity may be

Researchers have discovered that mouse skin and skin cells from humans produce pigmentation in response to sunlight on a 48-hour cycle. They observed that exposing skin to ultraviolet light every 2 days yielded darker pigmentation with less radiation damage than daily exposure. The findings appear October 25 in the journal Molecular Cell. “The damaging effects

WEDNESDAY, Oct. 17, 2018 — A precision map of a part of the brain of the lowly mouse could be a potent new research tool against Alzheimer’s, researchers say. The highly detailed look at the mouse hippocampus should provide new insight into a range of brain diseases in humans, according to the research team from

Children with autism often find social interactions awkward, leaving them isolated. Now in a study appearing in ACS’ Journal of Medicinal Chemistry, scientists report that they have discovered a first-of-its-kind compound that promotes social interaction among laboratory mice that display autistic traits. The finding could lead to the development of drugs capable of improving social

A heart attack triggers an acute inflammatory response, followed by resolution of inflammation and wound healing. A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death. In mouse experiments, University of Alabama at Birmingham scientists now have shown a way to hit an immunological “reset button” that

Excessive body fat is associated with negative effects on female fertility and pregnancy. In mice, maternal obesity impairs proper development of egg precursor cells called oocytes. In a recent paper published in Molecular & Cellular Proteomics, Qiang Wang and colleagues at the State Key Laboratory of Reproductive Medicine in China describe the link between poor