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Recruitment of miR-8080 by luteolin inhibits AR-V7 in castration-resistant prostate cancer

Prostate cancer is the most common noncutaneous malignancy in the United States and is responsible for many male deaths. The development of prostate carcinogenesis is initially androgen-dependent. However, the progression of castration-resistant prostate cancer (CRPC) following androgen deprivation therapy is a major clinical problem. Although enzalutamide and abiraterone have been approved for CRPC hormone therapy,

Diabetes in mothers raises risk of children having heart disease

Mothers-to-be with diabetes ‘face a greater risk of their children getting heart disease’  Scientists followed 2.4million children born in Denmark for 40 years Rates of early onset heart disease rose by 29% in people with diabetic mothers High glucose level has major implications for the development of a baby’s heart Mothers-to-be with diabetes may put

New treatment could ease the passage of kidney stones

Every year, more than half a million Americans visit the emergency room for kidney stone problems. In most cases, the stones eventually pass out of the body on their own, but the process can be excruciatingly painful. Researchers at MIT and Massachusetts General Hospital have now devised a potential treatment that could make passing kidney

Study of intestinal bacteria of insects may reveal strategies for combatting them

More than half the world’s population runs the risk of contracting infectious diseases transmitted by mosquitoes in the next few years. With climate change, these so-called arboviruses—once a problem concentrated in the planet’s tropical regions—appear to also be occurring in places with a temperate climate. “Recent studies indicate that the bacteria present in the intestine

Reducing the risk of infertility during endometriosis treatment

RUDN University physicians have measured the level of the Anti-Müllerian hormone, which indicates reproductive health, in patients with an ovarian cyst, and also assessed the likelihood of pregnancy after cyst removal surgery. The researchers have determined what types of cyst surgery are more effective than other treatments. The results are published in the European Journal

Excellent mental health for two-thirds of Indigenous people off reserve

Two-thirds (68%) of Indigenous people living off reserve in Canada have excellent mental health, according to a nationally representative study conducted by the University of Toronto and Algoma University. “These findings underline the incredible strength and resiliency of Indigenous people. Most previous research has focused solely on deficits. In contrast, our findings show that despite

Immune ‘checkpoint switch-off’ enables destruction of cancer cells

A collaboration between the Griffith Institute for Drug Discovery (GRIDD) and multiple clinical research institutes has led to an exciting discovery in cancer research. The multi-disciplinary team, led by GRIDD’s Dr. Alexandre Cristino and Professor Maher Gandhi from Mater Research and including researchers from the Translational Research Institute, discovered a new mechanism in which the

Narcissists: Why we need to take better care of them

Narcissists, like sharks, get a bad press. Both are generally seen as menacing, negative forces to be feared and avoided. But as any biologist will tell you, sharks play a vital role in the marine ecosystem. And it may be that narcissists also have a necessary part to play in human society. This of course,