Tag: Pancreatic Cancer

Inflammation of the pancreas is referred to as pancreatitis. The pancreas is a flat tadpole-shaped gland located at the back of the stomach in the upper abdomen; it releases certain enzymes and hormones which help in digestion and aids in regulating sugar metabolism in the body. Pancreatitis may manifest in both severe and acute forms.

A study published in Cell Reports Aug. 6 describes the generation of a new mouse model developed at Hollings Cancer Center that could lead to a better understanding of the cachexia syndrome. This wasting condition, characterized by excessive weight loss, has one of the highest incidence in pancreatic cancer patients. Denis Guttridge, Ph.D., Hollings Cancer

Known for its poor prognosis, lung adenocarcinoma is the most common type of lung cancer, responsible for about 4 of 10 diagnoses, according to the National Cancer Institute. Researchers on Mayo Clinic’s Florida campus can now distinguish between two pathways where this deadly cancer can develop. They say their discovery could help future patients. The

Biosensors are currently used in healthcare to monitor blood glucose; however, they also have the potential to detect bacteria. Researchers at Osaka University have invented a new biosensor using graphene — a material consisting of a one-atom-thick layer of carbon — to detect bacteria such as those that attack the stomach lining and that have

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in the world. Mostly chemoresistant, PDAC so far has no effective treatment. Understanding the connective tissue, called stroma, that surrounds, nurtures, and even protects PDAC tumors, is key to developing effective therapeutics. “PDAC patients are diagnosed really late, so we don’t know they’re

The incidence of colon and rectal cancer in adults younger than 50 years has increased substantially over the latest available 10-year period in several high-income countries, going against a decline or stabilisation trend in the incidence of colorectal cancers within the overall populations of high-income countries. This is according to an observational study published in

Cardiff University researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future. The team, at the University’s European Cancer Stem Cell Research Institute, found they could stop gastric cells dividing and growing by deleting a particular cell-surface receptor implicated in the function of stem

Scientists at The Wistar Institute and collaborators have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results, published online in Cell Reports, showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also

Human papillomavirus (HPV) is widely known to cause nearly all cases of cervical cancer. However, you might not know that HPV also causes 70 percent of oropharyngeal cancer, a subset of head and neck cancers that affect the mouth, tongue, and tonsils. Although vaccines that protect against HPV infection are now available, they are not

A team of researchers from Queen Mary University of London have reported the genetic events involved in the early development of bowel cancer in patients with inflammatory bowel disease (IBD). Such knowledge may be able to be exploited to design simple diagnostic tests to stratify patients with IBD at high risk of developing cancer. IBD

The most severe allergic reaction, anaphylaxis (or anaphylactic shock), is the result of an inappropriate immune reaction following the introduction of a usually harmless antigen into the body. The production of antibodies against this antigen (or allergen) allows the formation of antibody-antigen complexes that trigger a massive secretion of potent mediators, resulting in organ failure,

Colon cancer is the second most common cause of cancer-related deaths. The APC protein has long been known for its critical role in preventing colorectal cancer. When APC is inactivated, the development of colorectal cancer is triggered. Inactivation of APC is responsible for the vast majority (80%) of all colorectal cancers. Researchers from the laboratory

New insights into how cancer cells fuel their growth are opening novel possibilities for cancer treatment. A team of researchers at Baylor College of Medicine and Roswell Park Comprehensive Cancer Center has identified a long sought after connection between how cancer cells use the sugar glucose to generate energy — the Warburg pathway — and