Tag: pancreatic

Pancreatic cancer forms in the cells of the pancreas, an organ in the abdomen that releases enzymes that aid digestion and produces hormones that help manage our blood sugar levels. Pancreatic cancer is a rare disease with poor survival—it causes some 466,000 deaths internationally per year. The number of cases is increasing and the prognosis

According to a study published today in Gastroenterology by researchers at Virginia Commonwealth University Massey Cancer Center and University of Florida Health, Black, Hispanic, Indigenous and Asian Americans remain conspicuously absent from pancreatic cancer clinical trials aimed at testing the most recent treatment advances for this deadly disease.  Not only does this lack of diversity

Pancreatic cancer cells avert starvation by signaling to nerves, which grow into dense tumors and secrete nutrients. This is the finding of a study with experiments in cancer cells, mice, and human tissue samples published online November 2 in Cell. The study addresses pancreatic ductal adenocarcinoma (PDAC), the deadliest cancer of the pancreas with a

An experimental vaccine, designed to enlist the body’s own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. Researchers from the

Using a non-invasive imaging technique that measures the stiffness of tissues gives crucial new information about cancer architecture and could aid the delivery of treatment to the most challenging tumours, new research shows. Magnetic resonance elastography was able to visualise and measure how stiff and dense tumours are in mice. The technique, which can be

Researchers at the University of Toronto and University Health Network have found that standard pathology grading for the most common type of pancreatic cancer can be improved to better predict patient outcomes. The research shows that conventional, histological analysis of pancreatic tumours—based in part on morphology, or shape and structure—can better predict outcomes by taking

Jeopardy! host Alex Trebek is grateful at how well his body has responded to chemotherapy for his stage 4 pancreatic cancer — but his next mission, other than to make a full recovery, is to help shine a light on the disease so more can be done to help combat it. “The difference between the other

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines. GZ17-6.02 affects acetylation of the genes, reduces transcription of major transcription factors, sonic hedgehog pathway proteins, and stem cell markers. Dr.

A physician-scientist at the University of Arizona Cancer Center investigated a novel treatment for pancreatic cancer patients whose tumors exhibited a harmful genetic mutation. The results, in which a type of drug called a PARP inhibitor showed early promise in treating pancreatic cancer in patients with mutations in the BRCA gene, were published online last

Clinical trial results presented today at a prestigious cancer meeting in Chicago show substantial increased survival rates for pancreatic cancer patients who received a four-drug chemotherapy combination known as mFOLFIRINOX after surgery. Pancreatic cancer is typically very aggressive, with only approximately eight per cent of people surviving beyond five years after diagnosis, even after surgery

A new anti-cancer drug may be effective against a wider range of cancers than previously thought. Using a mouse model and samples taken from cancer patients, a team from the Technical University of Munich (TUM) has shown that a new class of drugs known as SHP2 inhibitors is also effective against aggressive, hard-to-treat tumors such

A type of molecular ‘rabble-rouser’ that triggers pancreatic cancer to become aggressive and spread around the body has been identified by scientists. The team behind the early-stage research, led by Imperial College London and funded by Pancreatic Cancer UK, say the findings may open avenues for treatments that target these molecules. The molecules, called microRNAs,