Tag: strains

Infectious proteins called prions cause a group of related, fatal and incurable neurodegenerative disorders, including bovine spongiform encephalopathy or Mad Cow disease and Creutzfeldt-Jakob disease, both of which affect humans. Chronic wasting disease or CWD, also caused by prions, has reached the point of a global epidemic among deer, elk and members of the deer

Rats are commonly used in nonclinical pharmaceutical studies to investigate the safety, efficacy and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics. The uridine 5′-diphospho-glucuronosyltransferase (Ugt) superfamily is