In Huntington’s disease, heart problems reflect broader effects of abnormal protein

Researchers investigating a key signaling protein in Huntington’s disease describe deleterious effects on heart function, going beyond the disease’s devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease. “Heart disease is the second leading cause

Experimental arthritis drug prevents stem cell transplant complication

An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research from Washington University School of Medicine in St. Louis shows. Studying mice, the researchers found the drug prevented what’s known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells

Detecting Alzheimer’s disease before it’s too late: Intervention long before the first signs of memory issues may be required to slow disease progression

The rate at which the protein beta-amyloid accumulates into the sticky plaques associated with Alzheimer’s disease (AD) is already slowing by the time a patient would be considered to have preclinical AD, according to a longitudinal study of healthy adults published in JNeurosci. The research suggests that anti-amyloid therapies would be most effective before individuals

People expect their memory to fade as early as their 50s

People across the UK expect their memory to worsen in their 50s, according to new research from Heriot-Watt University. The results from the “What Keeps You Sharp?” survey, released today, reveals the majority of those asked believe lifestyle and genetics are equally important contributors to the changes they might experience. Almost nine out of 10

Patients prefer doctors who engage in face-to-face visits

(HealthDay)—Patients prefer physicians who engage in face-to-face (F2F) clinic visits, rather than those using an examination room computer (ERC), according to a research letter published online April 19 in JAMA Oncology. Ali Haider, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues conducted a randomized controlled crossover study involving 120

Toxin floats on lipid rafts

Helicobacter pylori, the leading cause of peptic ulcer disease and stomach cancer. One factor important to H. pylori infection is the pore-forming toxin VacA. It is thought to gain entry into host cells by binding to specialized membrane domains called lipid rafts. Using Giant Plasma Membrane Vesicles (GPMVs), Anne Kenworthy, Ph.D., and colleagues studied how

Researchers use spider venom compound to treat paralysis

A team of Russian scientists together with foreign colleagues, reports that the venom of the crab spider Heriaeus melloteei may be used as a basis for a treatment against hypokalemic periodic paralysis. This disease is caused by genetic mutation that leads to the occurrence of the so-called ω-currents, or leakage currents, via voltage-gated ion channels

Drinking affects mouth bacteria linked to diseases

When compared with nondrinkers, men and women who had one or more alcoholic drinks per day had an overabundance of oral bacteria linked to gum disease, some cancers, and heart disease. By contrast, drinkers had fewer bacteria known to check the growth of other, harmful germs. These are the main findings of a study published