Tag: antibodies

A genetic modification in the ‘coat’ of a brain infection-causing virus may allow it to escape antibodies, according to Penn State College of Medicine researchers. They say testing people for this and other viral mutations may help identify patients at risk for developing a fatal brain disease. Dr. Aron Lukacher, professor and chair of the

Two different types of detectable antibody responses in SARS-CoV-2 (COVID-19) tell very different stories and may indicate ways to enhance public health efforts against the disease, according to researchers at The University of Texas MD Anderson Cancer Center. Antibodies to the SARS-CoV-2 spike protein receptor binding domain (S-RBD) are speculated to neutralize virus infection, while

A Phase 2 clinical trial will evaluate the safety and efficacy of potential new therapeutics for COVID-19, including an investigational therapeutic based on synthetic monoclonal antibodies (mAbs) to treat the disease. Researchers sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, are working with clinical sites

A novel study from the Institute of Environmental Medicine at Karolinska Institutet indicates that antibodies against a small lipid entity, phosphorylcholine (PC), can be associated with protection in inflammatory systemic diseases, including SLE and Sjögren’s syndrome. The results support evidence for a potential treatment by providing antibodies (anti-PC) to patients with these diseases or through

A team of researchers from Stanford University, the University of Cincinnati and Cincinnati Children’s Hospital Medical Center has found that people with peanut allergies have an abundance of allergy-causing immunoglobulin E antibodies (IgE) in their guts. In their paper published in the journal Science Immunology, the group describes sequencing antibody genes from B-lineage plasma cells

Researchers have cleared a major obstacle in the development of an HIV vaccine, proving in animal models that effective, yet short-lasting antibodies can be coaxed into multiplying as a fighting force against the virus. The finding, led by a team of researchers at the Duke Human Vaccine Institute (DHVI) and Boston Children’s Hospital, publishes online

The fight against infectious diseases: vaccines should now be chemical free In the production of vital vaccines are often used toxic chemicals. German researchers have now developed a novel technology that uses electron beams. This method allows you to be free for the first time, Dead vaccines, chemicals, quickly and reproducibly prepared. Protection against infectious

Scientists at The Wistar Institute and collaborators have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results, published online in Cell Reports, showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also

Antibodies could protect against heart attacks, according to a study by researchers from Imperial College London. The researchers, funded by the British Heart Foundation, studied patients with high blood pressure, of whom 87 had developed coronary heart disease. They also studied a further 143 patients who had their heart arteries extensively studied using cutting edge

Certain antibodies in a patient’s blood stream may enable life-threatening bacterial infections to spread instead of fighting them off, a University of Queensland study has found. UQ Diamantina Institute Senior Research Fellow Dr. Timothy Wells said the discovery may be helpful for treating or preventing sepsis in some patients in the future. Researchers examined how

Malaria is one of the most infectious diseases worldwide. Scientists from the German Cancer Research Center (DKFZ) in Heidelberg, Germany, and from the Hospital for Sick Children (SickKids) in Toronto, Canada, have studied how the human immune system combats malaria infections. In this study, the researchers discovered a previously unnoticed characteristic of antibodies against the

Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In the lab of biochemist and immunologist Christoph Rader, Ph.D., associate professor at The Scripps Research Institute in Florida, scientists have engineered a new type of anti-cancer antibody, one intended to enhance nature’s

Using an original mathematical and statistical analysis method, a team of scientists from the Institut Pasteur partnered with researchers from the United States and Thailand to analyze a Thai cohort that has long been a focus of study for dengue specialists, and obtained new information that should help identify individuals at risk of infection. By

Dr. Robert Britton firmly believes every molecule is important. This chemist doesn’t want any molecule sitting unused on a laboratory shelf or in a fridge. “I want every molecule to have a purpose—that’s my ethos for our lab,” says Britton, a GlycoNet network investigator and professor at Simon Fraser University. With that spirit in mind,

The most severe allergic reaction, anaphylaxis (or anaphylactic shock), is the result of an inappropriate immune reaction following the introduction of a usually harmless antigen into the body. The production of antibodies against this antigen (or allergen) allows the formation of antibody-antigen complexes that trigger a massive secretion of potent mediators, resulting in organ failure,

Scientists from the German Cancer Research Center (DKFZ) have been studying how the immune system succeeds in keeping pathogens in check. For the first time, the researchers have now discovered antibodies that are capable of disarming not only one specific bacterium, but a whole variety of microorganisms at once. The newly discovered antibodies recognize a