Tag: antibodies

Current monoclonal antibodies less potent against SARS-CoV-2 variants

The coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to wreak havoc across the globe. Scientists are racing to develop effective therapeutic regimens to combat the infection. One of therapy currently used to stimulate a robust immune response against the virus is monoclonal antibodies, a treatment used for

Immune response to SARS-CoV-2 may be limited by a set of genes

Neutralizing antibodies develop within two weeks of a SARS-CoV-2 infection, but their durability and intensity can vary by individual, prompting concerns about the prospects of long-lasting immunity and efficacy of COVID-19 vaccines. In a PLOS ONE paper, published online February 11, 2021, researchers at University of California San Diego School of Medicine report that individual

Detection of emerging SARS-CoV-2 variant in New York

Researchers at the California Institute of Technology in Pasadena have developed a software tool called "Variant Database" that has detected an emerging lineage of severe acute respiratory coronavirus 2 (SARS-CoV-2) isolates in New York. The novel SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to sweep the globe

SARS-CoV-2 evolves antibody resistance in immunocompromised patient

Researchers in the United States who tracked the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient found that convalescent plasma therapy was associated with the emergence of viral variants that were less susceptible to neutralizing antibodies. The SARS-CoV-2 virus is the agent responsible for the coronavirus 2019 (COVID-19) pandemic that

Study finds low SARS-CoV-2 antibody responses in asymptomatic and mild COVID-19 cases

The coronavirus disease 2019 (COVID-19) pandemic continues to spread across the globe. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the disease exhibits an array of clinical outcomes (from asymptomatic to critical). The majority of cases are asymptomatic or minimally symptomatic, wherein there are no symptoms or only a few manageable ones.

What are the Health Benefits of Breastfeeding?

Breastfeeding is still common and continues for a prolonged period in developing countries, whereas its rate has declined steeply in developed nations following the introduction of formula for babies. Women who immigrate to these regions tend to take on the lactational characteristics of their host countries around the beginning of the 19th century. Health Benefits

What is iDISCO?

Visualizing Structures within Tissue To see structure within biological tissue such as organs, it is necessary to first label the tissue. Antibodies are frequently used for this purpose, and this is known as “immunolabelling”. iDISCO: Adult mouse kidney, screen capture via https://www.youtube.com/watch?v=HCdSCMlNafk Antibodies are specific to certain “markers”, or antigens, and immunolabelling is used for

Benefits of Multiplex Immunoassays

How do you multiplex an immunoassay? There are two main ways of multiplexing an immunoassay; by separating the individual assays into different spaces (spatial separation) or by immobilizing antibodies onto different beads based on what they target. Jarun Ontakrai | Shutterstock Spatial separation is typically achieved by placing antibodies in different parts of a shared

Does the Immune System Differ between Men and Women?

Research has repeatedly shown that women have a stronger immune response to infections than men. Studies from as early as the 1940s have elucidated that women possess an enhanced capability of producing antibodies. Image Credit: Peterschreiber.media/Shutterstock.com Even though this builds an effective resistance barrier to infections, women have a higher predisposition to autoimmunity caused by

Frequently used serology test may not detect antibodies that could confirm protection against reinfection of COVID-19

Two different types of detectable antibody responses in SARS-CoV-2 (COVID-19) tell very different stories and may indicate ways to enhance public health efforts against the disease, according to researchers at The University of Texas MD Anderson Cancer Center. Antibodies to the SARS-CoV-2 spike protein receptor binding domain (S-RBD) are speculated to neutralize virus infection, while

Antibodies against phosphorylcholine give protection against rheumatic systemic disease

A novel study from the Institute of Environmental Medicine at Karolinska Institutet indicates that antibodies against a small lipid entity, phosphorylcholine (PC), can be associated with protection in inflammatory systemic diseases, including SLE and Sjögren’s syndrome. The results support evidence for a potential treatment by providing antibodies (anti-PC) to patients with these diseases or through

High levels of immunoglobulin E antibodies in microbiomes of people with peanut allergies

A team of researchers from Stanford University, the University of Cincinnati and Cincinnati Children’s Hospital Medical Center has found that people with peanut allergies have an abundance of allergy-causing immunoglobulin E antibodies (IgE) in their guts. In their paper published in the journal Science Immunology, the group describes sequencing antibody genes from B-lineage plasma cells

Dead vaccines with toxic chemicals manufactured

The fight against infectious diseases: vaccines should now be chemical free In the production of vital vaccines are often used toxic chemicals. German researchers have now developed a novel technology that uses electron beams. This method allows you to be free for the first time, Dead vaccines, chemicals, quickly and reproducibly prepared. Protection against infectious

Synthetic DNA-delivered antibodies protect against Ebola in preclinical studies

Scientists at The Wistar Institute and collaborators have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results, published online in Cell Reports, showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also

Antibodies cut heart attack risk

Antibodies could protect against heart attacks, according to a study by researchers from Imperial College London. The researchers, funded by the British Heart Foundation, studied patients with high blood pressure, of whom 87 had developed coronary heart disease. They also studied a further 143 patients who had their heart arteries extensively studied using cutting edge

‘Bad’ antibodies let blood infections rage

Certain antibodies in a patient’s blood stream may enable life-threatening bacterial infections to spread instead of fighting them off, a University of Queensland study has found. UQ Diamantina Institute Senior Research Fellow Dr. Timothy Wells said the discovery may be helpful for treating or preventing sepsis in some patients in the future. Researchers examined how