Tag: antibodies

Researchers in the United States who tracked the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient found that convalescent plasma therapy was associated with the emergence of viral variants that were less susceptible to neutralizing antibodies. The SARS-CoV-2 virus is the agent responsible for the coronavirus 2019 (COVID-19) pandemic that

The coronavirus disease 2019 (COVID-19) pandemic continues to spread across the globe. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the disease exhibits an array of clinical outcomes (from asymptomatic to critical). The majority of cases are asymptomatic or minimally symptomatic, wherein there are no symptoms or only a few manageable ones.

Breastfeeding is still common and continues for a prolonged period in developing countries, whereas its rate has declined steeply in developed nations following the introduction of formula for babies. Women who immigrate to these regions tend to take on the lactational characteristics of their host countries around the beginning of the 19th century. Health Benefits

Visualizing Structures within Tissue To see structure within biological tissue such as organs, it is necessary to first label the tissue. Antibodies are frequently used for this purpose, and this is known as “immunolabelling”. iDISCO: Adult mouse kidney, screen capture via https://www.youtube.com/watch?v=HCdSCMlNafk Antibodies are specific to certain “markers”, or antigens, and immunolabelling is used for

How do you multiplex an immunoassay? There are two main ways of multiplexing an immunoassay; by separating the individual assays into different spaces (spatial separation) or by immobilizing antibodies onto different beads based on what they target. Jarun Ontakrai | Shutterstock Spatial separation is typically achieved by placing antibodies in different parts of a shared

Research has repeatedly shown that women have a stronger immune response to infections than men. Studies from as early as the 1940s have elucidated that women possess an enhanced capability of producing antibodies. Image Credit: Peterschreiber.media/Shutterstock.com Even though this builds an effective resistance barrier to infections, women have a higher predisposition to autoimmunity caused by

A genetic modification in the ‘coat’ of a brain infection-causing virus may allow it to escape antibodies, according to Penn State College of Medicine researchers. They say testing people for this and other viral mutations may help identify patients at risk for developing a fatal brain disease. Dr. Aron Lukacher, professor and chair of the

Two different types of detectable antibody responses in SARS-CoV-2 (COVID-19) tell very different stories and may indicate ways to enhance public health efforts against the disease, according to researchers at The University of Texas MD Anderson Cancer Center. Antibodies to the SARS-CoV-2 spike protein receptor binding domain (S-RBD) are speculated to neutralize virus infection, while

A Phase 2 clinical trial will evaluate the safety and efficacy of potential new therapeutics for COVID-19, including an investigational therapeutic based on synthetic monoclonal antibodies (mAbs) to treat the disease. Researchers sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, are working with clinical sites

A novel study from the Institute of Environmental Medicine at Karolinska Institutet indicates that antibodies against a small lipid entity, phosphorylcholine (PC), can be associated with protection in inflammatory systemic diseases, including SLE and Sjögren’s syndrome. The results support evidence for a potential treatment by providing antibodies (anti-PC) to patients with these diseases or through

A team of researchers from Stanford University, the University of Cincinnati and Cincinnati Children’s Hospital Medical Center has found that people with peanut allergies have an abundance of allergy-causing immunoglobulin E antibodies (IgE) in their guts. In their paper published in the journal Science Immunology, the group describes sequencing antibody genes from B-lineage plasma cells

Researchers have cleared a major obstacle in the development of an HIV vaccine, proving in animal models that effective, yet short-lasting antibodies can be coaxed into multiplying as a fighting force against the virus. The finding, led by a team of researchers at the Duke Human Vaccine Institute (DHVI) and Boston Children’s Hospital, publishes online

The fight against infectious diseases: vaccines should now be chemical free In the production of vital vaccines are often used toxic chemicals. German researchers have now developed a novel technology that uses electron beams. This method allows you to be free for the first time, Dead vaccines, chemicals, quickly and reproducibly prepared. Protection against infectious

Scientists at The Wistar Institute and collaborators have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results, published online in Cell Reports, showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also

Antibodies could protect against heart attacks, according to a study by researchers from Imperial College London. The researchers, funded by the British Heart Foundation, studied patients with high blood pressure, of whom 87 had developed coronary heart disease. They also studied a further 143 patients who had their heart arteries extensively studied using cutting edge

Certain antibodies in a patient’s blood stream may enable life-threatening bacterial infections to spread instead of fighting them off, a University of Queensland study has found. UQ Diamantina Institute Senior Research Fellow Dr. Timothy Wells said the discovery may be helpful for treating or preventing sepsis in some patients in the future. Researchers examined how

Malaria is one of the most infectious diseases worldwide. Scientists from the German Cancer Research Center (DKFZ) in Heidelberg, Germany, and from the Hospital for Sick Children (SickKids) in Toronto, Canada, have studied how the human immune system combats malaria infections. In this study, the researchers discovered a previously unnoticed characteristic of antibodies against the

Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In the lab of biochemist and immunologist Christoph Rader, Ph.D., associate professor at The Scripps Research Institute in Florida, scientists have engineered a new type of anti-cancer antibody, one intended to enhance nature’s

Using an original mathematical and statistical analysis method, a team of scientists from the Institut Pasteur partnered with researchers from the United States and Thailand to analyze a Thai cohort that has long been a focus of study for dengue specialists, and obtained new information that should help identify individuals at risk of infection. By

Dr. Robert Britton firmly believes every molecule is important. This chemist doesn’t want any molecule sitting unused on a laboratory shelf or in a fridge. “I want every molecule to have a purpose—that’s my ethos for our lab,” says Britton, a GlycoNet network investigator and professor at Simon Fraser University. With that spirit in mind,