Neuroinflammatory diseases, including Alzheimer’s disease and traumatic brain injury, have been linked to deposits of a tough protein known as fibrin, derived from the blood clotting factor fibrinogen. These mesh-like fibrin deposits occur outside blood vessels in the brain, contributing to the death of certain central nervous system cells (neurons) that eventually leads to impaired
For the first time, researchers at the University of Gothenburg have shown that metastases in patients with malignant melanoma gain access to the circulatory system not only through the outgrowth of new blood vessel branches, but also an alternative process in which one blood vessel divides into two parallel vessels by longitudinal splitting. The finding
Ischemic stroke, the second leading cause of death worldwide, occurs when a vessel to the brain is blocked, reducing blood flow to the brain and depriving it of critical supplies of oxygen and nutrients. This process leads to the death of brain cells and leaves the patient with a sudden loss of certain body functions.
Mosquitoes can and do feed on HMBPP-supplemented beetroot juice. This is the findings of a study at Stockholm University. HMBPP is a metabolite which is produced by Malaria parasite, Plasmodium. The researchers have shown that it is possible to mimic a blood meal so closely that mosquitoes naturally prefer this artificial solution by using HMBPP
Mesenchymal stem cells (MSCs) are thought to have great potential in the field of regenerative medicine, which has the aim of restoring damaged tissues. However, not much was known about in vivo plasticity of them—until now. Researchers have identified a subpopulation of MSCs that promote the healing of bone fractures and show an enhanced ability
People with rare disorders that cause shortened telomeres — protective caps that sit at the end of chromosomes — may be more likely to have blood cancers such as leukemia or myelodyplastic syndrome. Now, Johns Hopkins Medicine scientists have discovered several "self-correcting" genetic mutations in bone marrow that may protect such patients from these cancers.
Researchers from the Skolkovo Institute of Science and Technology and Saratov State University have come up with an inexpensive method for visualizing blood flow in the brain. The new technique is so precise it discerns the motions of individual red blood cells—all without the use of toxic dyeing agents or expensive genetic engineering. The study
In some children with acute myeloid leukemia, cancer cells have as many DNA changes as healthy blood stem cells. Researchers were surprised to find these children have a poorer chance of survival compared with children whose leukemia has an above-average number of DNA changes. Their new study offers insight into how this form of blood
A new report from the long-term ASPREE study, involving Monash University, has revealed high blood pressure variability (BPV) in older adults, particularly in men, is associated with an increased risk of dementia and cognitive decline. Published in the Journal of the American Heart Association, the findings may identify people at increased risk of major cognitive
Using simple blood tests could help researchers identify children who have been misidentified as having severe malaria, according to a study published today in eLife. Researchers are working to develop better ways to treat severe malaria, which kills about 400,000 children in Africa each year. The discovery could help expedite such research by helping them
Evidence continues to mount that vaccination against COVID-19, most notably the Pfizer and Moderna vaccines, produces robust, durable protection in the vast majority of recipients. But questions remain for some at greatest risk of a severe outcome from a COVID-19 infection: Recipients of donor organs and bone marrow whose immune systems are necessarily suppressed to
Hypertension is a chronic disease that can lead to serious health problems. Patients with arterial hypertension are required to measure their blood pressure at home, which can have some drawbacks, such as forgetting to checkitor recordingthe values, errors in writing downthe figures,the inability to immediately notify health care staff about out-of-range blood pressure values, etc.
International organizations and countries around the world are working to eliminate HIV/AIDS by 2030. To reach this goal, new approaches are needed–particularly among difficult-to-reach groups such as people who inject drugs (PWID), who are 30 times more likely to contract HIV/AIDS compared with the general population. Matthew Akiyama, M.D., assistant professor of medicine at Albert
Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new mechanism that activates specific genes, leading to the development of cancers. They showed that a mutation that fuses two unrelated genes can promote a process similar to that observed when oil and water are
Smokers needed their blocked arteries fixed nearly a decade earlier than non-smokers, and patients with obesity underwent these procedures four years earlier than non-obese patients, according to a new statewide study. The research included patients without a history of heart attack who were treated at hospitals across Michigan participating in BMC2, the Blue Cross Blue
One challenge as society reopens is identifying who has been vaccinated for SARS-CoV-2, the virus that causes COVID-19. A team of Johns Hopkins researchers has developed a rapid blood test that could confirm a person has been vaccinated while they wait to board a plane or enter a sporting event. Their COVID-19 antibody test is
Shortage of hematologists or specialists to treat blood disorders in Africa requires urgent action, experts say. The acute shortage of hematologists in Sub-Saharan Africa has given rise to an urgent need for training to help address increasing cases of blood disorders, scientists say. The World Health Organization (WHO) recommends one clinical hematologist per 100,000 people
Researchers at the University of Turku, Finland, showed that the antibody treatment reactivates the immune defense in patients with advanced-stage cancer. The treatment alters the function of the body's phagocytes and facilitates extensive activation of the immune system. The immune defense is the body's own defense system equipped to combat cancer. However, cancer learns to
Parkinson's disease (PD) is a common neurodegenerative disorder caused by the death of dopaminergic neurons in a part of the brain (known as substantia nigra pars compacta), which leads to a deficit of dopamine (DA), one of the main neurotransmitters active in the central nervous system. Symptomatic treatment focuses on increasing the concentration of dopamine
Antibodies aren't the only immune cells needed to fight off COVID-19 -; T cells are equally important and can step up to do the job when antibodies are depleted, suggests a new Penn Medicine study of blood cancer patients with COVID-19 published in Nature Medicine. The researchers found that blood cancer patients with COVID-19 who