Tag: Breast Cancer

Scientists map interactions between head and neck cancer and HPV virus: Connecting the dots between human papillomavirus and smoking-related cancers

Human papillomavirus (HPV) is widely known to cause nearly all cases of cervical cancer. However, you might not know that HPV also causes 70 percent of oropharyngeal cancer, a subset of head and neck cancers that affect the mouth, tongue, and tonsils. Although vaccines that protect against HPV infection are now available, they are not

Mitochondria come together to kill cancer cells: Uncovered details of a molecular pathway in cancer cells could lead to improved treatment

A team of Hokkaido University scientists studied the molecules involved in mitochondrial movements within highly invasive breast cancer cells. They identified a pathway that ultimately leads to the dispersion of these energy-generating organelles towards the cells’ periphery, increasing cancer invasiveness. When this pathway was blocked, mitochondria aggregated within the cell’s center, where they started overproducing

Researchers compare chemotherapy regimens for best outcomes in invasive bladder cancer: Less-frequently used combination associated with better response than standard of care

Patients with muscle-invasive bladder cancer have been shown to benefit from chemotherapy prior to surgical removal of the bladder. But which type of chemotherapy leads to the best outcomes in terms of complete response rates or cancer control? Moffitt Cancer Center researchers examined data from more than 800 surgical patients with advanced bladder cancer. The

Combination approach shows promise for beating advanced melanoma: New treatment is more effective in people receiving immunotherapy for the first time, study finds

A UCLA-led study has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin cancer, live longer. The research showed that using the immunotherapy drug pembrolizumab and the experimental agent SD-101, a sequence of nucleic acids that mimics

Marijuana found in breast milk up to six days after use: Researchers report 63 percent of breast milk samples from mothers using marijuana contained traces of the drug

With the legalization of marijuana in several states, increased use for both medicinal and recreational purposes has been documented in pregnant and breastfeeding women. Although national organizations like the American Academy of Pediatrics recommend that breastfeeding mothers do not use marijuana, there has been a lack of specific data to support health or neurodevelopmental concerns

Nuclear gatekeeper could block undruggable prostate cancer targets

Certain molecular drivers of cancer growth are “undruggable” — it’s been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting information through a gate in the nucleus, where the instructions are carried out. Researchers at the Sidney Kimmel Cancer Center — Jefferson

Mechanisms of action of key genetic abnormality in Ewing sarcoma: Epigenome editing reveals how a fusion protein found in cancer cells enhances the expression of target genes

A Massachusetts General Hospital (MGH) research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma — the second most common bone cancer in children and young adults — unleashes tumor growth. In their paper in the journal Genes & Development the researchers show that blocking the fusion protein

Lung cancer death rate for women may rise to 40% by 2030

In an alarming new research study, researchers have stated that lung cancer mortality rates among women could increase by 43% by 2030. The findings are according to an analysis of data from 52 countries. The global age-standardised breast cancer mortality rate is projected to decrease by 9% in the same time frame. Globally, among women,

A study points to new therapeutic targets for tumors associated with chronic inflammation: A new study demonstrates that myeloid cells use p38 protein signalling to support inflammation-associated colon cancer

Scientists headed by ICREA researcher Angel R. Nebreda at the Institute for Research in Biomedicine (IRB Barcelona) report a new mechanism that contributes to the development of inflammation-associated colon cancer and points to new therapeutic targets. The study has been published in the journal EMBO Molecular Medicine. More than a million people worldwide are diagnosed

New study confirms higher cancer rate in women with dense breast tissue

Researchers using automated breast density measurements have found that women with mammographically dense breast tissue have higher recall and biopsy rates and increased odds of screen-detected and interval breast cancer, according to a large new study from Norway published online in the journal Radiology. The study supports automated measurements as a future standard to ensure

Negative vs. positive social media experiences and depressive symptoms

Negative experiences on social media carry more weight than positive interactions when it comes to the likelihood of young adults reporting depressive symptoms, according to a new University of Pittsburgh analysis. The finding, reported today in the journal Depression and Anxiety, may be useful for designing interventions and clinical recommendations to reduce the risk of

Childhood cancer: The four survival strategies of tumor cells

Cancer cells in children tend to develop by following four main trajectories — and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumour, according to the study that is now published in Nature Genetics. The researchers

Cancer cells co-opt pain-sensing ‘wasabi receptor’ to survive oxidative stress: Antioxidants and the TRPA1 channel protein complement each other to increase tumor survival

Anyone who’s taken a bite of a sandwich with too much spicy mustard or a piece of sushi with too much wasabi can attest to the tear-inducing sensation these condiments can cause. These loud warnings to the nervous system of exposure to potentially harmful chemicals are triggered by TRPA1, a calcium channel protein sometimes referred