Tag: component

Missing sodium-channel component may protect against diet-induced artery stiffening

New research in mice finds that deficiency in one small component of a signaling pathway may protect against artery stiffening and subsequent kidney disease associated with a high-fat, high-sugar diet. The study is published in the American Journal of Physiology-Renal Physiology. Consuming a western diet—typically high in fat and refined carbohydrates, including sugar—is associated with

Missing component of innate immune signaling identified

How cells recognize pathogens and alert the immune system swiftly is a fundamental process of high importance for the survival of any species, including humans. A key role is ascribed to so-called adapters—little molecular platforms inside cells where signals from pathogen detectors are integrated for safety and accuracy and conveyed to lasting signals leading to