Tag: Huntington’s

A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington’s disease. This large, international project, which included a collaboration between the National Institute of Neurological

Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington’s disease in a new study published today in eLife. The research in mice indicates that targeting the histamine H3 receptor (H3R) – a well-established drug target for other conditions such as hay fever—could help to prevent imbalances in dopamine signaling that lead

About 40 percent of the affected patients with Huntington’s disease—a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease. An altered function of Cdk5 kinase—an essential enzyme in several cell signalling pathways- could explain the physiopathology of the depressive-like behaviour in Huntington’s disease, according

The neurological disorder Huntington’s disease causes behavioural and motor changes, which among other things are a result of dysfunctional maturation or formation of glial cells, the brain’s support cells, researchers from the University of Copenhagen demonstrate in a new study based on mouse trials. The researchers’ long-term goal is to be able to use the

Researchers at Lund University in Sweden have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington’s disease. The results pave the way for the development of new treatment strategies for diseases that involve impairment of the basic mechanism by

Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans. In unveiling RA’s epigenome—the proteins and molecules that decorate DNA and help

Researchers investigating a key signaling protein in Huntington’s disease describe deleterious effects on heart function, going beyond the disease’s devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease. “Heart disease is the second leading cause