Tag: inhibits

Prostate cancer is the most common noncutaneous malignancy in the United States and is responsible for many male deaths. The development of prostate carcinogenesis is initially androgen-dependent. However, the progression of castration-resistant prostate cancer (CRPC) following androgen deprivation therapy is a major clinical problem. Although enzalutamide and abiraterone have been approved for CRPC hormone therapy,

Hepatitis C virus (HCV) is a hepatotropic virus, with about 80 million chronic infections confirmed worldwide. HCV infection leads to the development of chronic hepatitis, cirrhosis, and in some instances, hepatocellular carcinoma. The recent development of highly potent direct-acting antiviral drugs (DAAs), targeting viral proteins, facilitates virus elimination in >90 percent of treated individuals. However,