Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung function in adulthood, researchers at Vanderbilt University Medical Center have discovered. In a mouse model, deleting the gene for beta-1 integrin from the epithelial cells lining the alveoli of the adult lung, where the exchange of oxygen and carbon dioxide
Doctors told to consider shortness of breath and coughing as symptoms of LUNG CANCER because they are the earliest signs of the killer disease Researchers examined 27,795 records of patients from across the country They had been diagnosed with lung cancer between year 2000 and 2017 Rate of coughs and shortness of breath increased as
A team of researchers at the University of California, Riverside, used automated computer methods to mine a large online discussion forum for electronic cigarette users and found this group reported numerous adverse health effects for at least seven years. The research, published in the Journal of Medical Internet Research, shows health problems associated with e-cigarettes
Vaping is just as likely as smoking to cause persistent lung infections ‘because e-cigarette vapour causes bacteria to become more harmful’ E-cigarette vapour containing nicotine caused harmful bacteria to form, grow Researchers found it had similar effect on bugs as traditional cigarette smoke Warn devices could be even more harmful as users take deeper, longer
People who are diagnosed with the most common form of asbestos-related lung disease are not at an increased risk of developing lung cancer later in life, a new study led by Curtin University has found. The research, published in the American Journal of Respiratory and Critical Care Medicine, examined the relationship between asbestos-related pleural plaques
Do you think I DESERVE to have incurable lung cancer? How one mother deals with the accusation that her terminal illness is self-inflicted having smoked 10 cigarettes a day When I first tell people I have terminal lung cancer, I’m usually met by one of three responses. Most commonly, it’s a concerned tilt of the
Only about 6 in 10 lung cancer patients in the United States receive the minimal lung cancer treatments recommended by the National Comprehensive Cancer Network guidelines, according to new research published online in the Annals of the American Thoracic Society. In “Disparities in Receiving Guideline-Concordant Treatment for Lung Cancer in the United States,” Erik F.
The invention of interactive map applications has revolutionized wayfinding, providing an unprecedented level of information far beyond what printed road maps can offer. Researchers at Children’s Hospital Los Angeles are giving us a similar look into the anatomy of the human lung, and their findings could help babies breathe easier. Infants born prematurely often suffer
In adolescent and adult patients with cystic fibrosis taking lumacaftor-ivacaftor (ORKAMBI), the combination drug appears to improve lung function and body weight and reduce the need for intravenous antibiotic treatment, according to a French study published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. However, nearly one in five
Nintedanib, a medication approved for the treatment of idiopathic pulmonary fibrosis, slows the decline in lung function among patients with a broad range of scarring lung diseases. The findings, published in the New England Journal of Medicine, suggest that many more people may benefit from nintedanib than are currently approved for treatment. They also suggest
A clinical trial testing the toxicity of a KRAS inhibitor demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation, according to research presented today at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study of
Bowel cancer begins in the bowel. Depending on where the cancer starts, bowel cancer is sometimes called colon or rectal cancer. Symptoms of bowel cancer can include a change in a person’s normal bowel habit or blood in their poo. People can experience additional symptoms if the cancer is spread to the lungs. As Mayo
A unique clinic for patients with terminal lung disease is leading to dramatic reductions in hospital deaths, better symptom management and lower costs for the health-care system. The multidisciplinary team at Alberta Health Services’ Kaye Edmonton Interstitial Lung Disease Clinic delivers palliative care and encourages treatment at home for patients with idiopathic pulmonary fibrosis (IPF).
Implemented back in 2005, the lung allocation score is used to prioritize patients awaiting lung transplants in the United States. Sicker transplant candidates have a higher calculated score and are placed at the top of the list. But a recent study led by Maryam Valapour, M.D., MPP, director of Lung Transplant Outcomes in Cleveland Clinic’s
For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. The research from the Wellcome Sanger Institute, University Medical Center Groningen, Open Targets, GSK and collaborators revealed the identity of each cell type, creating the first draft Human Cell Atlas of the
Results from a study published in the Journal of the National Medical Association show that a pragmatic system-based intervention within cancer treatment centers can nearly eliminate existing disparities in treatment and outcomes for black patients with early-stage lung and breast cancer. The treatment completion rates before this intervention were 87.3 percent for white patients versus
A new method of determining the sequence of molecules in DNA can be used to detect small fragments of cancerous genetic material in blood samples from lung cancer patients with a high degree of accuracy, according to new research published in the leading cancer journal Annals of Oncology today. Results from analyses of so-called “liquid
An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. Cystic fibrosis is a lifelong
Immune cells called T cells are key components in the fight against cancer. However, they sometimes struggle to recognize cancerous cells or to launch an appropriate response against them. T cell activity can be tweaked to improve anticancer effects using cancer immunotherapy, but this is only effective for a subset of patients, who are difficult
New strides are being made toward the ex vivo growth of human lungs. In a new article published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, researchers report the development of a high-throughput, automated, multichannel lung bioreactor that allows parallel culture of up to five human cell-populated isolated rat lung scaffolds.