Tag: lung

Team tracks integrin’s role in lung function

Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung function in adulthood, researchers at Vanderbilt University Medical Center have discovered. In a mouse model, deleting the gene for beta-1 integrin from the epithelial cells lining the alveoli of the adult lung, where the exchange of oxygen and carbon dioxide

Doctors told to consider coughing as symptom of LUNG CANCER

Doctors told to consider shortness of breath and coughing as symptoms of LUNG CANCER because they are the earliest signs of the killer disease Researchers examined 27,795 records of patients from across the country They had been diagnosed with lung cancer between year 2000 and 2017 Rate of coughs and shortness of breath increased as

Vaping 'could be WORSE than smoking for lung disease', study finds

Vaping is just as likely as smoking to cause persistent lung infections ‘because e-cigarette vapour causes bacteria to become more harmful’ E-cigarette vapour containing nicotine caused harmful bacteria to form, grow  Researchers found it had similar effect on bugs as traditional cigarette smoke  Warn devices could be even more harmful as users take deeper, longer

Do you think I DESERVE to have incurable lung cancer?

Do you think I DESERVE to have incurable lung cancer? How one mother deals with the accusation that her terminal illness is self-inflicted having smoked 10 cigarettes a day When I first tell people I have terminal lung cancer, I’m usually met by one of three responses. Most commonly, it’s a concerned tilt of the

A higher resolution image of human lung development

The invention of interactive map applications has revolutionized wayfinding, providing an unprecedented level of information far beyond what printed road maps can offer. Researchers at Children’s Hospital Los Angeles are giving us a similar look into the anatomy of the human lung, and their findings could help babies breathe easier. Infants born prematurely often suffer

CF patients experience improved lung health with lumacaftor-ivacaftor but with caveats

In adolescent and adult patients with cystic fibrosis taking lumacaftor-ivacaftor (ORKAMBI), the combination drug appears to improve lung function and body weight and reduce the need for intravenous antibiotic treatment, according to a French study published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. However, nearly one in five

Phase 1 study shows novel KRAS inhibitor well tolerated by patients with adenocarcinoma and non-small cell lung cancer

A clinical trial testing the toxicity of a KRAS inhibitor demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation, according to research presented today at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study of

Innovative patient-centred lung clinic reduces suffering along with costs

A unique clinic for patients with terminal lung disease is leading to dramatic reductions in hospital deaths, better symptom management and lower costs for the health-care system. The multidisciplinary team at Alberta Health Services’ Kaye Edmonton Interstitial Lung Disease Clinic delivers palliative care and encourages treatment at home for patients with idiopathic pulmonary fibrosis (IPF).

First lung map uncovers new insights into asthma

For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. The research from the Wellcome Sanger Institute, University Medical Center Groningen, Open Targets, GSK and collaborators revealed the identity of each cell type, creating the first draft Human Cell Atlas of the

Trial remedies racial disparities in treatment for early-stage lung and breast cancer patients

Results from a study published in the Journal of the National Medical Association show that a pragmatic system-based intervention within cancer treatment centers can nearly eliminate existing disparities in treatment and outcomes for black patients with early-stage lung and breast cancer. The treatment completion rates before this intervention were 87.3 percent for white patients versus

Treatment to a T? Taking a ‘BiTE’ out of lung cancer

Immune cells called T cells are key components in the fight against cancer. However, they sometimes struggle to recognize cancerous cells or to launch an appropriate response against them. T cell activity can be tweaked to improve anticancer effects using cancer immunotherapy, but this is only effective for a subset of patients, who are difficult

Multichannel bioreactor for lung regeneration analysis

New strides are being made toward the ex vivo growth of human lungs. In a new article published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, researchers report the development of a high-throughput, automated, multichannel lung bioreactor that allows parallel culture of up to five human cell-populated isolated rat lung scaffolds.