Tag: Pharmacology

When Navy SEALs carry out dives in Arctic waters, or when rescue teams are diving under ice-covered rivers or ponds, the survival time even in the best wetsuits is very limited — as little as tens of minutes, and the experience can be extremely painful at best. Finding ways of extending that survival time without

A new study from University of Illinois at Chicago researchers suggests that more than one-third of U.S. adults may be using prescription medications that have the potential to cause depression or increase the risk of suicide, and that because these medications are common and often have nothing to do with depression, patients and health care

Scientists have zeroed in on a culprit that spurs damaging inflammation in the heart following a heart attack. The guilty party is a type of immune cell that tries to heal the injured heart but instead triggers inflammation that leads to even more damage. Further, the researchers have found that an already approved drug effectively

A new SLAS Discovery article available now for free ahead-of-print, offers perspective from researchers at Coyne Scientific (Atlanta, GA) about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials. The pharmaceutical industry is facing unprecedented challenges as the cost of developing new drugs reaches unsustainable levels, fueled in

A team of Texas A&M and Texas A&M AgriLife Research scientists now have a deeper understanding of a large switch/sucrose non-fermentable (SWI/SNF) protein complex that plays a pivotal role in plant and human gene expression that causes life-threatening diseases such as cancer. Their findings could lead to more targeted therapies and help with physiological improvements

Attempted vaginal birth after cesarean (VBAC) is associated with higher rates of adverse effects or death for mothers and infants, although absolute rates were low in mothers who attempted this type of birth, according to research in CMAJ (Canadian Medical Association Journal). “The absolute rates of adverse maternal and neonatal outcomes are low with both

Many bacteria are equipped with a flagellum, a helical propeller that allows bacteria to travel. The flagellum is assembled in a highly organized manner involving the stepwise addition of each of its internal parts. However, there are many open questions as to how this orderly construction is achieved. In a study published in Science Advances,

It has been estimated that there are more than 10^100 possible materials that can be synthesised, grown, and optimised. Materials design can be a slow and laborious process and investigating the full parameter space is a formidable challenge. Machine learning and other advanced statistical techniques will almost certainly help accelerate materials discovery, design, and optimisation,

Making tiny changes to existing diabetes treatments can alter how they interact with cells, and potentially make the medicines more effective. The findings come from early-stage studies in both human cells and mice in which researchers tweaked the structure of an existing treatment for type 2 diabetes. This tweak enabled the researchers, from Imperial College

Two genetically modified broadly neutralizing antibodies (bNAbs) protected rhesus macaques from an HIV-like virus, report scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. After introducing genetic mutations into two potent HIV bNAbs, researchers prepared intravenous infusions of two bNAbs known as 3BNC117-LS and 10-1074-LS. Single

In a mouse study, a drug that has helped millions of people around the world manage their diabetes might also help people ready to kick their nicotine habits. In a report published this week in Proceedings of the National Academy of Sciences (PNAS), investigators say metformin, an inexpensive drug commonly used to treat patients with