Tag: proteins

Inhibition of proteins activated by nitric oxide reverses aortic aneurysm in Marfan syndrome

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) pathway is overactivated in the aortas of mice and patients with Marfan Syndrome and that the activity of this pathway causes the aortic aneurysms that characterize this disease. The results of the study,

Scientists uncover proteins essential for memory B cell survival

Signals from two key proteins are essential for the survival of our ‘immunological memory’, according to new research from scientists at the Francis Crick Institute, published in the Journal of Experimental Medicine. Memory B cells are long-lived cells that confer immunological memory by providing rapid and robust antibody responses to infections our body has seen

Muscle-building proteins hold clues to ALS, muscle degeneration

Toxic protein assemblies, or “amyloids,” long considered to be key drivers in many neuromuscular diseases, also play a beneficial role in the development of healthy muscle tissue, University of Colorado Boulder researchers have found. “Ours is the first study to show that amyloid-like structures not only exist in healthy skeletal muscle during regeneration, but are

Discovery links DNA-packaging proteins and cancer development

University of Otago scientists have unravelled the 3-D structure of two proteins, potentially providing answers as to why some people may be at risk of developing specific cancers. In new findings published today in leading journal Nature Communications, the team of researchers led by the Department of Biochemistry’s Dr. Peter Mace, has solved the structure