Tag: Rats

Rats are commonly used in nonclinical pharmaceutical studies to investigate the safety, efficacy and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics. The uridine 5′-diphospho-glucuronosyltransferase (Ugt) superfamily is

Washington State University researchers have seen cognitive changes in the offspring of rats exposed to heavy amounts of cannabis. Their work is one of the rare studies to look at the effects of cannabis during pregnancy. The drug is the most commonly used illicit substance among pregnant women. Ryan McLaughlin, an assistant professor of Integrative

THURSDAY, Nov. 1, 2018 — Rats developed cancer after being exposed to high levels of cellphone radiation, but those levels were much higher than what people are exposed to when using their cellphones, a new government report says. When exposed to radio frequency radiation like that used in 2G and 3G cellphones, male rats developed

Adult rats that had been exposed before birth and during nursing to a mixture of chemicals found in a wide range of consumer products have a smaller medial prefrontal cortex (mPFC) and perform worse on an attention-switching task than rats not exposed to the chemicals early in life. These findings, published in JNeurosci, demonstrate a

Stroke is the most common cause of adult disability. This is due not only to the high incidence of stroke, but also because spontaneous recovery is often incomplete and no drugs are available that hasten recovery. Mesencephalic astrocyte-derived neurotrophic factor MANF is neuroprotective when administered before experimental stroke in rats. A massive immune response mediated

Understanding how neighborhood dynamics regulate mosquito bites is key to managing diseases like West Nile virus and Zika virus. Today in Parasites & Vectors, researchers report that in Baltimore, Maryland, socioeconomic differences between neighborhoods influence bite risk, with rats being a primary blood meal source in lower income neighborhoods. Shannon LaDeau, a disease ecologist at