Tag: Rodents

Scientists are batting a thousand in a project to reconstruct the mouse brain’s wiring diagram. Researchers at the Howard Hughes Medical Institute’s Janelia Research Campus have now carefully unraveled a tangle of more than 1,000 neurons, tracing each cell’s branching route across the brain to pinpoint where it goes and to which cells it connects.

A new experimental antibiotic for tuberculosis has been shown to be more effective against TB than isoniazid, a decades-old drug which is currently one of the standard treatments. In mouse studies, the new drug showed a much lower tendency to develop resistance, and it remains in the tissues where the Mycobacterium tuberculosis bacteria reside for

Heat waves can reduce the body’s immune response to flu, according to new research in mice at the University of Tokyo. The results have implications for how climate change may affect the future of vaccinations and nutrition. Climate change is predicted to reduce crop yields and nutritional value, as well as widen the ranges of

Experimenting with mice, Johns Hopkins Medicine researchers report that a low-calorie diet prevented asthma symptoms regardless of the diet’s fat and sugar content. The researchers also say they found that obesity resulting from a high-calorie diet led to asthma symptoms in the animals by causing lung inflammation, and a drug that blocks inflammation eased those

The rat in a maze may be one of the most classic research motifs in brain science, but a new innovation described in Cell Reports by an international collaboration of scientists shows just how far such experiments are still pushing the cutting edge of technology and neuroscience alike. In recent years, scientists have shown that

Consuming too much vitamin A may decrease bone thickness, leading to weak and fracture prone bones, according to a study published in the Journal of Endocrinology. The study, undertaken in mice, found that sustained intake of vitamin A, at levels equivalent to 4.5-13 times the human recommended daily allowance (RDA), caused significant weakening of the

Using male individuals has long been a tradition in scientific mice studies. But new research enforces the importance of using a balanced population of male and female mice. In a paper published May 22 in the journal Cell Reports, scientists studying the locus coeruleus brain structure in mice unexpectedly found substantial differences in the molecular

Everyday products carry environmental chemicals that may be making us fat by interfering with our hormones, according to research presented in Barcelona at the European Society of Endocrinology annual meeting, ECE 2018. Following recommendations on how to avoid these chemicals could help minimise exposure and potentially reduce the risk of obesity and its complications. Obesity

In a study of mice, National Institutes of Health-funded researchers describe a new circuit involved in fine-tuning the brain’s decision either to hide or confront threats. The study, published in Nature, was partially funded by the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. “Being able to manipulate specific circuits can uncover surprising relationships

Chronic caloric restriction consists in eating a reduced but balanced diet from early adult life onward. Previous research, into macaques in particular (which have an average lifespan of forty years), had already demonstrated its beneficial effect on the incidence of age-related pathologies. However, its positive effect on the lifespan of primates remained controversial. To study