Tag: Targeting

Researchers at Dartmouth’s and Dartmouth-Hitchcock’s Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it. Anti-estrogen treatments, which block growth signals from estrogen receptors (ER) in tumors, are effective treatments for ER+ breast cancer. But it is common for breast tumors

It’s the third deadliest cardiovascular diagnosis, but doctors are still often stumped to explain why 40% of patients experience unprovoked venous thromboembolism (VTE). And after a patient has dealt with these dangerous blood clots once, a second and subsequent events become much more likely. New research from a team of University of Michigan scientists may

Depression, obesity and chronic pain could all be treated ‘by blocking the SAME protein’ Scientists blocked protein FKBP51 for the first time without also affecting others Hope will lead to treatment in humans; FKBP51 is also being tested in cancer FKBP51 has many functions from regulating glucose to stress management  e-mail 8 View comments Depression, obesity

Researchers have developed a new nuclear medicine tracer that could improve diagnosis and treatment of non-small cell lung cancer. Research published in the November issue of The Journal of Nuclear Medicine found that the new tracer, 99mTc-HYNIC-cMBP, produced clearer images in less time than currently used tracers and was more rapidly eliminated from the body,

Rhabdomyosarcoma (RMS) is a rare cancer of the skeletal muscle that primarily affects pediatric patients. After diagnosis, about 3 out of 4 patients are cured with standard treatment. Survival rates drop to 17 percent if the disease comes back (recurs) and to 30 percent if it spreads (metastasizes). “RMS has among the worst survival statistics

Brain tumours account for 20 per cent of all cases of childhood cancers as well as the highest number of cancer-related deaths in Canadian children under 20 years old. Despite improved clinical outcomes, patients live with extensive cognitive and physical delays resulting from toxicities associated with chemotherapy and radiation. “Better, more targeted and less toxic

One of the most common causes of congestive heart failure is “stiff heart syndrome.” According to Dr. Jerry Sokol — a cardiologist in Deer Park, NY — this causes fluid to build up and back up into the lungs. This occurs “usually in patients older than age 60,” he says. At the microcellular level, they

Proteins commonly known as BRCA—short for BReast CAncer susceptibility gene- serve a critical role in cellular DNA repair, but when mutated they allow genetic errors to replicate, facilitating cancer development. If the BRCA repair system is disabled in cancer cells, the cells simply turn to backup repair mechanisms and adapt to alternative repair pathways, a

Women with an aggressive form of breast cancer who have faults in their BRCA genes do much better on chemotherapy drug carboplatin than standard treatment, a major clinical trial reports. Researchers found that women with advanced ‘triple-negative’ breast cancer who had inherited a BRCA mutation were twice as likely to benefit from carboplatin as docetaxel,

Researchers from the University of Dundee have identified an enzyme critical for cell division that could potentially be targeted to tip tumours ‘over the edge’ into remission. A team led by Professor Paul Clarke and Dr. Adrian Saurin, from the University’s School of Medicine, discovered that the enzyme USP9X controls the proper timing of cell