Tag: vaccine

Virologists select SARS-CoV-2 vaccine candidate for clinical trials

Virologists at the Rega Institute at KU Leuven (Belgium) have developed a vaccine candidate that protects hamsters from infection with the SARS-CoV-2 coronavirus. Theirs is one of the first vaccine candidates that is proven to protect lab animals from infection. The team aims to start clinical trials next Winter. Their findings are pending peer review,

NIH ACTIV working group weighs human challenge studies for SARS-CoV-2 vaccine development

In a Perspective for the New England Journal of Medicine, members of the National Institutes of Health’s Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group assess practical considerations and prerequisites for using controlled human infection models (CHIMs), which can be used for human challenge studies, to support SARS-CoV-2 vaccine development. In the article,

Brazil to help test Oxford coronavirus vaccine

An experimental vaccine against the new coronavirus developed at the University of Oxford will be tested from mid-June in Brazil, the first country outside Britain to take part in the study, researchers said Wednesday. The vaccine will be tested in Brazil on 2,000 volunteers, who will be recruited starting this week, said the Federal University

Monkeys, ferrets offer needed clues in COVID-19 vaccine race

The global race for a COVID-19 vaccine boils down to some critical questions: How much must the shots rev up someone’s immune system to really work? And could revving it the wrong way cause harm? Even as companies recruit tens of thousands of people for larger vaccine studies this summer, behind the scenes scientists still

Inroads to a better Ebola vaccine

As the world focuses on finding a COVID-19 vaccine, research continues on other potentially catastrophic pandemic diseases, including Ebola and Marburg viruses. The world cannot afford to take our eye of other threats, says Flinders University Professor Nikolai Petrovsky, who warns the highly lethal and infectious Ebola virus could appear in a more virulent form.

Germany warns vaccine could take ‘years’

Germany’s health minister said developing a vaccine for the coronavirus could take “years”, after Donald Trump predicted it could be achieved by the end of 2020. “I would be delighted if it was possible to achieve this in a few months,” Jens Spahn said late Sunday on ARD television. “But it can also take years

Scientists are already working on a coronavirus vaccine

Scientists are already working on a coronavirus vaccine – but warn it will likely be years before there is a shot to prevent the contagious illness which has so far killed 17 people A new coronavirus has sickened more than 500 people worldwide and killed 17 in China, where it originated  The first US case

Researchers develop a faster, stronger rabies vaccine

Every year, more than 59,000 people around the world die of rabies and there remains no cheap and easy vaccine regimen to prevent the disease in humans. Now, researchers report in PLOS Neglected Tropical Diseases that adding a specific immune molecule to a rabies vaccine can boost its efficacy. Previous studies have suggested that the

Advance in search for new Clostridioides difficile vaccine

Scientists have made a breakthrough in the hunt for a new vaccine for killer hospital bug Clostridioides difficile (C. diff). University of Exeter researchers first identified a gene in C. diff responsible for producing a protein that aids in binding the bacteria to the gut of its victims. In collaboration with researchers at Paris-SUD University,

We have a vaccine for hepatitis B, but we still need a cure

Hepatitis B is blood-borne virus that packs a punch. Worldwide, more than 1.3 billion people have been infected with hepatitis B, and 257 million people have developed a life-long infection. This includes 240,000 Australians, many of whom are Indigenous. Globally, transmission most commonly occurs from mother to baby or in early life. But it’s possible

Herpes vaccine is a winner in animals. Next up: Testing on humans.

For nearly a century, efforts to develop a vaccine to prevent genital herpes have failed. At least nine prospects, including several that made it to late-stage human testing, have flopped in the last decade. Considering that history, University of Pennsylvania scientists are justifiably excited about their vaccine against the herpes simplex 2 virus, even though

Survey: many U.S. adults not planning to get flu vaccine

(HealthDay)—Many U.S. adults, including some at the highest risk for the flu and pneumonia, do not plan to get preventive vaccines, according to a survey conducted by NORC at the University of Chicago on behalf of the National Foundation for Infectious Diseases. The survey was conducted between Aug. 15 and 18, 2019, to better understand

Vaccine against deadly superbug Klebsiella effective in mice

Scientists have produced and tested, in mice, a vaccine that protects against a worrisome superbug: a hypervirulent form of the bacteria Klebsiella pneumoniae. And they’ve done so by genetically manipulating a harmless form of E. coli, report researchers at Washington University School of Medicine in St. Louis and VaxNewMo, a St. Louis-based startup. Klebsiella pneumoniae causes

New vaccine targets killer disease tuberculosis

There is only one existing vaccine for TB and it is not effective in adults. Researchers at the Centenary Institute and University of Sydney will next test their new vaccine in clinical trials with humans. Australian medical researchers from the Centenary Institute and the University of Sydney have successfully developed and tested on mice a

Recommendations developed for japanese encephalitis vaccine

(HealthDay)—In the July 19 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report, recommendations are presented for use of the Japanese encephalitis (JE) vaccine. Susan L. Hills, M.B.B.S., from the National Center for Emerging and Zoonotic Infectious Diseases at the CDC in Fort Collins, Colorado, and colleagues summarize the