Tag: tuberculosis

Earlier diagnosis and treatment assessment of tuberculosis achieved with pet/ct

Research presented at the Society of Nuclear Medicine and Molecular Imaging’s 2019 Annual Meeting shows that molecular imaging with 18F-FDG positron emission tomography/computed tomography (PET/CT) can evaluate tuberculosis at the molecular level, effectively identifying diseased areas and guiding treatment for patients. According to the World Health Association, tuberculosis is one of the top 10 causes

How ‘superbug’ E. coli clones take over human gut

A ‘superbug’ clone of E. coli has evolved to prevent itself from becoming so dominant that it could potentially wipe out the bacteria from existence, scientists led by the University of Birmingham have discovered. The researchers investigated how and why a clone of E. coli called ST131 — dubbed a ‘superbug’ because it is resistant

New tools and strategies for tuberculosis diagnosis, care, and elimination: A PLOS Medicine special

This week, publication of a special issue on tuberculosis (TB) begins in PLOS Medicine, advised by guest editors Richard Chaisson of Johns Hopkins University, Claudia Denkinger of the University of Heidelberg, and Mark Hatherill of the South African Tuberculosis Vaccine Institute. An estimated 10 million people developed tuberculosis (TB) and 1.6 million died of TB

Drug-resistant tuberculosis: A new study offers new hope

Tuberculosis (TB) is the leading cause of death in the world from a single infectious disease, causing more deaths than HIV/AIDS. In 2017, 10 million people developed TB disease globally and an estimated 1.6 million died. One of the biggest blocks to beating the epidemic is the growing resistance to drugs that have previously cured

New tuberculosis drug may shorten treatment time for patients

A new experimental antibiotic for tuberculosis has been shown to be more effective against TB than isoniazid, a decades-old drug which is currently one of the standard treatments. In mouse studies, the new drug showed a much lower tendency to develop resistance, and it remains in the tissues where the Mycobacterium tuberculosis bacteria reside for

South Asians at risk for tuberculosis often are not tested

Many South Asian immigrants from countries where tuberculosis (TB) is common do not get tested even though they are at high risk for developing the disease, according to a recent study by Rutgers University and St. Peter’s University Hospital. Tuberculosis, which mainly affects the lungs, kills more people worldwide—about 1.6 million—than any other single infectious

Managing the complexities and risks of HIV and tuberculosis coinfection

A new study identified a significant association between HIV infection and complexities of treating patients with tuberculosis coinfection. Patients with HIV were more likely to have more tuberculosis drug-related adverse events, more hospital readmissions, and longer tuberculosis treatment duration, as reported in AIDS Research and Human Retroviruses, a peer-reviewed journal from Mary Ann Liebert, Inc.,

Governments to discuss tackling tuberculosis at UN summit

Governments from around the world will gather Wednesday to discuss the persistent scourge of tuberculosis, which last year claimed more lives than any other communicable disease. About 1.3 million people worldwide died of TB in 2017. A further 300,000 people with both HIV and TB died in last year, according to World Health Organization figures

How damaging immune cells develop during tuberculosis

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues. Foam cells are a type of white blood cell, known as

How damaging immune cells develop during tuberculosis

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues. Foam cells are a type of white blood cell, known as

New imaging technique can spot tuberculosis infection in an hour

Guided by glowing bacteria, researchers have devised an imaging technique that can diagnose live tuberculosis in an hour and help monitor the efficacy of treatments. That’s particularly critical because many TB strains have evolved defenses against standard treatments. Jianghong Rao, PhD, a professor of radiology at Stanford who led the work, says that speedy TB

Childhood infections may have lasting effects on school performance

Severe infections leading to hospitalizations during childhood are associated with lower school achievement in adolescence,reports a study in the July issue of The Pediatric Infectious Disease Journal (PIDJ). In the nationwide study of nearly 600,000 Danish children, higher numbers of hospitalizations for infections were associated with a reduced probability of completing ninth grade, as well

Clinical trials in a dish: A perspective on the coming revolution in drug development

A new SLAS Discovery article available now for free ahead-of-print, offers perspective from researchers at Coyne Scientific (Atlanta, GA) about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials. The pharmaceutical industry is facing unprecedented challenges as the cost of developing new drugs reaches unsustainable levels, fueled in