Tag: advanced

Additional data, advanced analytics improve performance of machine learning referral app

Research scientists from Regenstrief Institute and Indiana University have further improved the performance of Uppstroms, a machine learning application that identifies patients who may need referrals to wraparound services, by incorporating additional personal and population-level data sources and advanced analytical approaches. Research team affiliations include Regenstrief, IU Fairbanks School of Public Health at IUPUI, IU

New AI technology for advanced heart attack prediction

Technology developed using artificial intelligence (AI) could identify people at high risk of a fatal heart attack at least 5 years before it strikes, according to new research funded by the British Heart Foundation (BHF). The findings are being presented at the European Society of Cardiology (ESC) Congress in Paris and published in the European

Advanced computational modeling of the gut for biodefense

The Nutritional Immunology and Molecular Medicine Laboratory (NIMML) has developed a high-resolution model of the gut immune system by using advanced computational systems. The new high-performance computing (HPC)-driven model of the gut predicts new emerging behaviors and responses to biological threats. The gut ecosystem includes trillions of interactions between host epithelial and immune cells, molecules

New insights into treatment targets for men with advanced prostate cancers

A study published recently in the Journal of Clinical Oncology Precision Oncology, an American Society of Clinical Oncology (ASCO) journal, outlines findings from the largest-ever prospective genomic analysis of advanced prostate cancer tumors. Using comprehensive genomic profiling (CGP) to analyze thousands of tumor samples from men with advanced prostate cancers, the researchers identified that 57

New way to target advanced breast cancers

A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target. A research team led by Karolina Palucka, M.D., Ph.D., a professor at The Jackson Laboratory (JAX), has collaborated with researchers at The Baylor Institute for Immunology

Pembrolizumab Not Better Than PTX for Advanced Gastric Cancer

MONDAY, July 2, 2018 — For patients with previously treated advanced gastric cancer or gastro-esophageal junction cancer, pembrolizumab does not result in a significant improvement in overall survival compared with paclitaxel, according to a study published online June 4 in The Lancet. Kohei Shitara, M.D., from National Cancer Center Hospital East in Kashiwa, Japan, and

Long-lasting radionuclide therapy for advanced neuroendocrine tumors proves effective

A first-in-human study presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) demonstrates the benefits and safety of a new, long-lasting type of radionuclide therapy for patients with advanced, metastatic neuroendocrine tumors (NETs). Lutathera-177 (177Lu)-DOTATATE (trade name Lutathera), a peptide receptor radionuclide tharapy (PRRT) with radiolabeled somatostatin analogues

Drug combination slows growth of most common type of advanced breast cancer

The combination of taselisib and fulvestrant has shown to slow the growth of cancer in post-menopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2) negative, PIK3CA-mutant, inoperable, locally advanced or metastatic breast cancer. Researchers from Memorial Sloan Kettering Cancer Center (MSK) presented this data, from the SANDPIPER trial, in a press conference

Some people with advanced kidney cancer could avoid surgery

The targeted drug sunitinib (Sutent) is as effective alone as when it’s combined with surgery for some people with advanced kidney cancer, according to a clinical trial. This means some people whose kidney cancer has spread could in future avoid having surgery to remove the affected organ. Average survival times were as good in patients

Nursing home residents with advanced dementia have lower mortality rate with hip surgery

Researchers from Hebrew SeniorLife’s Institute for Aging Research and Brown University have conducted the first study to examine outcomes in nursing home residents with advanced dementia and hip fracture. They discovered that advanced dementia residents have a lower mortality rate after 6 months, if they undergo surgical repair. Those advanced dementia patients managed with surgery

For mothers with advanced cancer, parenting concerns affect emotional well-being

Parenting concerns contributed significantly to the psychological distress of mothers with late-stage cancer, according to a study by University of North Carolina Lineberger Comprehensive Cancer Center researchers. Cancer is the leading cause of disease-specific death for parenting-age women in the United States, and women with incurable cancer who have children can have increased rates of