Tag: advanced

Blowing air from a fan into the face of patients with advanced cancer experiencing breathlessness, and other nonpharmacologic interventions, may offer symptom relief, according to new research directed by Johns Hopkins Kimmel Cancer Center investigators. On the other hand, the investigators found medications, such as opioids, had limited impact in improving breathlessness. In a systematic

WEDNESDAY, Nov. 18, 2020 — Vitamin D supplementation is associated with a reduction in the incidence of advanced cancer, with the strongest reduction seen among those with normal weight, according to a study published online Nov. 18 in JAMA Network Open. Paulette D. Chandler, M.D., M.P.H., from Harvard Medical School in Boston, and colleagues conducted

Research scientists from Regenstrief Institute and Indiana University have further improved the performance of Uppstroms, a machine learning application that identifies patients who may need referrals to wraparound services, by incorporating additional personal and population-level data sources and advanced analytical approaches. Research team affiliations include Regenstrief, IU Fairbanks School of Public Health at IUPUI, IU

Advanced bowel cancer cells have very few “molecular flags” on their surface, helping to explain why they may be hard for the immune system to detect, a new study has shown. Molecules on the surface of tumor cells, arising from faults in their DNA, help the immune system pick them out as cancerous—enabling immune cells

Technology developed using artificial intelligence (AI) could identify people at high risk of a fatal heart attack at least 5 years before it strikes, according to new research funded by the British Heart Foundation (BHF). The findings are being presented at the European Society of Cardiology (ESC) Congress in Paris and published in the European

Prostate cancer is cancer of the prostate gland. The prostate is a small gland at the base of the bladder. It is about the size of a walnut but gets bigger as men get older. Initial symptoms of prostate cancer tend to show up once the prostate is large enough to affect the tube that

The Nutritional Immunology and Molecular Medicine Laboratory (NIMML) has developed a high-resolution model of the gut immune system by using advanced computational systems. The new high-performance computing (HPC)-driven model of the gut predicts new emerging behaviors and responses to biological threats. The gut ecosystem includes trillions of interactions between host epithelial and immune cells, molecules

A study published recently in the Journal of Clinical Oncology Precision Oncology, an American Society of Clinical Oncology (ASCO) journal, outlines findings from the largest-ever prospective genomic analysis of advanced prostate cancer tumors. Using comprehensive genomic profiling (CGP) to analyze thousands of tumor samples from men with advanced prostate cancers, the researchers identified that 57

A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target. A research team led by Karolina Palucka, M.D., Ph.D., a professor at The Jackson Laboratory (JAX), has collaborated with researchers at The Baylor Institute for Immunology

MONDAY, July 2, 2018 — For patients with previously treated advanced gastric cancer or gastro-esophageal junction cancer, pembrolizumab does not result in a significant improvement in overall survival compared with paclitaxel, according to a study published online June 4 in The Lancet. Kohei Shitara, M.D., from National Cancer Center Hospital East in Kashiwa, Japan, and

A first-in-human study presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) demonstrates the benefits and safety of a new, long-lasting type of radionuclide therapy for patients with advanced, metastatic neuroendocrine tumors (NETs). Lutathera-177 (177Lu)-DOTATATE (trade name Lutathera), a peptide receptor radionuclide tharapy (PRRT) with radiolabeled somatostatin analogues

The combination of taselisib and fulvestrant has shown to slow the growth of cancer in post-menopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2) negative, PIK3CA-mutant, inoperable, locally advanced or metastatic breast cancer. Researchers from Memorial Sloan Kettering Cancer Center (MSK) presented this data, from the SANDPIPER trial, in a press conference

The targeted drug sunitinib (Sutent) is as effective alone as when it’s combined with surgery for some people with advanced kidney cancer, according to a clinical trial. This means some people whose kidney cancer has spread could in future avoid having surgery to remove the affected organ. Average survival times were as good in patients

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have developed a 3-D brain organoid that could have potential applications in drug discovery and disease modeling. This is the first engineered tissue equivalent to closely resemble normal human brain anatomy, containing all six major cell types found in normal organs including, neurons and immune cells. In

Researchers from Hebrew SeniorLife’s Institute for Aging Research and Brown University have conducted the first study to examine outcomes in nursing home residents with advanced dementia and hip fracture. They discovered that advanced dementia residents have a lower mortality rate after 6 months, if they undergo surgical repair. Those advanced dementia patients managed with surgery

Parenting concerns contributed significantly to the psychological distress of mothers with late-stage cancer, according to a study by University of North Carolina Lineberger Comprehensive Cancer Center researchers. Cancer is the leading cause of disease-specific death for parenting-age women in the United States, and women with incurable cancer who have children can have increased rates of