Tag: Biochemistry Research

Genetic risk is associated with differences in gut microbiome

Children with a high genetic risk of developing type 1 diabetes have different gut microbiomes than children with a low risk, according to a new study from Linköping University in Sweden and the University of Florida in the US. The results published in the scientific journal Nature Communications suggest that genetic risk can shape an

Information technology can support antimicrobial stewardship programs: SHEA white paper outlines the role of EHR and ‘add on’ clinical decision support

The incorporation of information technology (IT) into an antimicrobial stewardship program can help improve efficiency of the interventions and facilitate tracking and reporting of key metrics, including outcomes, according to a Society for Healthcare Epidemiology of America (SHEA) white paper published in the society’s journal Infection Control & Hospital Epidemiology. “When used intentionally, information technology

Physicists find the limits of multitasking in biological networks

Many complex systems in biology can be conceptualized as networks. This perspective helps researchers understand how biological systems work on a fundamental level, and can be used to answer key questions in biology, medicine, and engineering. Blood flow in the brain is a prime example. Blood travels through a network of vessels and can be

Herpes viruses and tumors evolved to learn how to manipulate the same ancient RNA: Findings could have implications for drugs and insight into diseases like Alzheimer’s

Herpes viral infections use the ancient genetic material found in the human genome to proliferate, mimicking the same process tumors have been found to manipulate, Mount Sinai researchers have shown for the first time. These observations provide further insight about how herpes viruses can manipulate the immune system in ways that may drive neurodegenerative diseases

Making mice a tiny bit more human to study preterm birth: Research enhances ability to study biology of persistent public health problem

Preterm birth remains a global epidemic linked to a lifetime of potential health complications. It also is difficult to study in living creatures — especially the uniquely precise biology of preterm birth in humans. Researchers report in PLoS Biology successfully inserting just enough human DNA into transgenic laboratory mice that it allowed the team to

Viruses under the microscope

Human herpesvirus 6 (HHV-6) infects almost all of the human population, but only very few will show any symptoms during their lifetime: HHV-6 is one of the most widespread viruses among the population. Between 95 and 100 percent of healthy adults have antibodies to the virus which means that they have been infected at some

New technique reveals how Zika virus interacts inside our cells: Discovery could enable development of new anti-viral therapies

Scientists have developed a new technique that can determine how viruses interact with a host’s own RNA. As well as providing insight into how viruses direct the host cell to create new virus particles, this technique, published today in Nature Methods, could allow researchers to design artificial molecules capable of blocking the virus replication process

Chromatin structure: Slip-sliding away…

In the cell nucleus, the genomic DNA is packaged into a tightly condensed form, which is referred to as chromatin. The basic unit of chromatin organization is the nucleosome, a DNA-protein complex consisting of a defined length of DNA wrapped around a bead-like structure which is made of histone proteins. The individual nucleosomes are connected

How enzyme detects ultraviolet light damage

Damage to DNA is a constant threat to cellular life, and so it is constantly monitored and detected by a family of enzymes called RNA polymerases, resulting in subsequent repair to maintain genome integrity. In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with

Characteristics of microorganisms most likely to cause a global pandemic

Infectious disease preparedness work focuses predominantly on an historical list of pathogens derived from biological warfare agents, political considerations, and recent outbreaks. That fails to account for the most serious agents not currently known or without historical precedent, write scholars from the Johns Hopkins Center for Health Security in a new report on the traits