Tag: Cancer

New research from Lund University in Sweden shows that inflammatory, unstable atherosclerotic plaque has a metabolism that differs from that of stable plaque – and is similar to that of cancer cells. Future research will therefore investigate whether cancer drugs could potentially be used to treat cardiovascular disease. Atherosclerotic plaque builds up gradually in the

Researchers from the University of Dundee have identified an enzyme critical for cell division that could potentially be targeted to tip tumours ‘over the edge’ into remission. A team led by Professor Paul Clarke and Dr. Adrian Saurin, from the University’s School of Medicine, discovered that the enzyme USP9X controls the proper timing of cell

Chronic lymphocytic leukemia (CLL) is a haematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. To ensure their survival and growth, CLL cells are able to establish a microenvironment in

Every year, health care providers in the United States discover more than 1.6 million lung nodules in patients. Many are “incidentally detected,” meaning they are found during evaluation for an unrelated cause (for example, a chest X-ray after a fall). Although 75 to 85 percent of these incidentally detected nodules turn out to be benign,

The standard of care for kidney cancer patients continues to improve. The U.S. Food and Drug Administration granted approval to the combination of two immunotherapy drugs, ipilimumab and nivolumab, for the treatment of metastatic kidney cancer. The results of the large, international clinical trial leading to the approval were just published the prestigious New England

Most of the roughly 15.5 million cancer survivors in the U.S. receive chemotherapy, and roughly 65 percent develop some degree of the chemotherapy-induced nerve damage known as peripheral neuropathy. Peripheral neuropathy simply means nerves outside of the brain and spinal cord are affected, and symptoms include numbness and tingling in extremities, and in about 30

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high-resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer. This achievement has been made possible by using high-resolution cryo-electron microscopy, a technique brought to the CNIO thanks to

Patients with advanced prostate cancer who received more intensive treatment experienced worse quality of life three months after treatment, but a better quality of life in the long term, compared to those on standard therapy, according to a new Northwestern Medicine study. The findings were published in the Journal of Clinical Oncology. “Treatment of prostate

A new view of a protein frequently mutated in pituitary tumors is overturning conventional wisdom and could point to novel targets for cancer drugs. The protein, a “G protein” called Gαs, initiates messages inside cells. But a single mutation alters Gαs action in a surprising way. The protein’s molecular “off switch” actually switches activity on,

Researchers at the University of Sydney have established a method to identify individual nanoparticles released by human cells, opening the way for them to become diagnostic tools in the early-detection of cancers, dementia and kidney disease. The particles, known as extracellular vesicles, or EVs, are routinely released by cells and play a central role in

(HealthDay)—For patients with breast cancer, endocrine therapy-induced alopecia (EIA) has a pattern that is similar to androgenetic alopecia, according to a study published online April 11 in JAMA Dermatology. Azael Freites-Martinez, M.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues conducted a retrospective cohort study to characterize EIA in 112

A Purdue University-patented technology shows promise in using microscopic bubbles filled with oxygen to help with various medical treatments, including improving cancer therapeutics and helping wounds heal faster. Samara Biotech LLC, a Purdue startup, has developed an easy-to-use method to inject oxygen “nanobubbles” intravenously so they can be targeted precisely at wounds or cancerous tumors.

Because testicular cancer has a 95 percent cure rate, it is easier for men to move on and forget about it. But new research in the Journal of Clinical Oncology shows that it’s prudent for patients to stay in touch with their medical team as they age and to be aware of treatment toxicities. The

Two common iron compounds increase the formation of a known biomarker for cancer, according to a new study of cancer cells from Chalmers University of Technology, Sweden. The two compounds, ferric citrate and ferric EDTA, are often used in dietary supplements and as a food additive respectively, in worldwide markets including the U.S. and the

Further evidence that immunotherapy provides long-term survival benefit for patients with lung cancer was presented today at ELCC 2018 (European Lung Cancer Congress) in Geneva, Switzerland. Researchers presented the three-year survival results of the randomised phase 2 POPLAR trial in second line, which is the longest follow-up reported to date with anti-programmed death ligand 1

Researchers from Mount Sinai and Sema4, a health information company and Mount Sinai venture, have discovered that giving metastatic bladder cancer patients simultaneous chemotherapy and immunotherapy is safe and that patients whose tumors have certain genetic mutations may respond particularly well to this combination approach, according to the results of a clinical trial published in

A multi-institutional research team has identified what may be a novel mechanism underlying acquired resistance to CDK 4/6 inhibitor treatment for breast cancer. In their report published in the Annals of Oncology, the team—led by investigators at Massachusetts General Hospital (MGH), Institute Gustave Roussy in Paris, and Texas Oncology-Baylor Sammons Cancer Center/U.S. Oncology in Dallas—reports

New research on bowel cancer has shown that every tumour is different, and that every cell within the tumour is also genetically unique. In the first study of its kind, researchers from the Wellcome Sanger Institute, UK and Hubrecht Institute (KNAW) in Utrecht, The Netherlands, used the latest single cell and organoid technologies to understand

A new study in the Journal of the National Cancer Institute, published by Oxford University Press, indicates that high-quality cervical cancer screening can be done effectively using a completely automated approach. The researchers involved in the study indicate that automated technology could increase cervical screening coverage in underserved regions. Cervical cancer is caused by persistent

Adding the monoclonal antibody drug trastuzumab—already used to treat certain breast cancers—to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value.