Tag: Caregiving

A new drug target for chemically induced Parkinson’s disease

More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson’s disease. In a new study led by scientists from the School of Veterinary Medicine, researchers found that an enzyme in the body can metabolize compounds formed in the brain from alkaloids

One step closer to chronic pain relief

Sortilin, which is a protein expressed on the surface of nerve cells, plays a crucial role in pain development in laboratory mice — and in all likelihood in humans as well. This is the main conclusion of the study ‘Sortilin gates neurotensin and BDNF signalling to control peripheral neuropathic pain’, which has just been published

Appendix removal associated with development of Parkinson’s disease: Data from 62 million records explores relationship between the gut and the nervous system disorder

Patients who had their appendix removed were more likely to develop Parkinson’s disease than those whose appendix remained in place, according to the largest study to address the relationship between the two conditions. The retrospective study involving more than 62 million patient records from 26 health systems will be presented at Digestive Disease Week® (DDW)

Researchers define Alzheimer’s-like brain disorder: LATE symptoms resembles Alzheimer’s disease but has different cause

A brain disorder that mimics symptoms of Alzheimer’s disease has been defined with recommended diagnostic criteria and guidelines for advancing future research on the condition. Researchers at Rush University Medical Center and scientists from several National Institutes of Health-funded institutions, in collaboration with international peers, described the newly-named pathway to dementia, Limbic-predominant Age-related TDP-43 Encephalopathy,

Scientists propose new theory on Alzheimer’s, amyloid connection

Worldwide, 50 million people are living with Alzheimer’s disease and other dementias. According to the Alzheimer’s Association, every 65 seconds someone in the United States develops this disease, which causes problems with memory, thinking and behavior. It has been more than 100 years since Alois Alzheimer, M.D., a German psychiatrist and neuropathologist, first reported the

Soil compound fights chronic wasting disease

A major compound in soil organic matter degrades chronic wasting disease prions and decreases infectivity in mice, according to a study published November 29 in the open-access journal PLOS Pathogens by Judd Aiken of the University of Alberta, and colleagues. Chronic wasting disease is an environmentally transmissible, fatal prion disease affecting free-ranging deer, moose, elk

Discovery could explain failed clinical trials for Alzheimer’s, and provide a solution

Researchers at King’s College London have discovered a vicious feedback loop underlying brain degeneration in Alzheimer’s disease which may explain why so many drug trials have failed. The study also identifies a clinically approved drug which breaks the vicious cycle and protects against memory-loss in animal models of Alzheimer’s. Overproduction of the protein beta-amyloid is

Sugar pills relieve pain for chronic pain patients: Placebo benefits can be predicted by brain anatomy and psychological traits

Someday doctors may prescribe sugar pills for certain chronic pain patients based on their brain anatomy and psychology. And the pills will reduce their pain as effectively as any powerful drug on the market, according to new research. Northwestern Medicine scientists have shown they can reliably predict which chronic pain patients will respond to a

Common painkillers triple harmful side effects in dementia: Commonly-prescribed opioid-based painkillers led to harmful side effects tripling in people with dementia

Commonly-prescribed opioid-based painkillers led to harmful side effects tripling in people with dementia. Researchers from the University of Exeter, King’s College London and the University of Bergen are presenting two studies at the Alzheimer’s Association International Conference 2018 (AAIC) highlighting a significant increase in harmful side effects related to the use of commonly prescribed opioid

Genomic medicine may one day revolutionize cardiovascular care

A new scientific statement from the American Heart Association summarizes the state-of-the-science of genomic medicine — the study of the health effects of the molecular interactions of a person’s unique genes — for studying cardiovascular traits and disorders and for therapeutic screening. “The promise of genomic medicine is to be able to use a patient’s

In-home therapy effective for stroke rehabilitation, study shows: A multisite US clinical trial compared home-based telerehabilitation program with traditional in-clinic rehabilitation therapy

In-home rehabilitation, using a telehealth system and supervised by licensed occupational/physical therapists, is an effective means of improving arm motor status in stroke survivors, according to findings presented by University of California, Irvine neurologist Steven C. Cramer, MD, at the recent 2018 European Stroke Organisation Conference in Gothenburg, Sweden. “Motor deficits are a major contributor

Are pain tolerance levels similar among groups of friends?

Are your friends very pain tolerant? Then it is likely that you are as well, provided you are a male. A recent study, published in the Scandinavian Journal of Pain, along with an Editorial Comment by Dr. Jeffrey Mogil, published by De Gruyter, shows that there is a positive correlation between the pain tolerance of

Preparing for the ‘silver tsunami’: Law professor suggests how to address nation’s looming health-care and economic crisis caused by surging baby-boom population

Skyrocketing drug prices and the looming insolvency of Social Security and Medicare are just two of many pressing issues caused by America’s surging baby-boom population, often referred to as the “Silver Tsunami.” What can be done about it? In a recent article published in The Elder Law Journal, Sharona Hoffman, the Edgar A. Hahn Professor