Tag: cell

What is a Cell Proliferation Assay?

Cell growth and division result in an increase in the number of cells. This is known as cell proliferation. To measure this, cell proliferation assays are utilized. This article will discuss what cell proliferation assays are and why measuring cell proliferation is important. Image Credit: unoL/Shutterstock.com What is a cell proliferation assay? Cell proliferation assays

Protein network map uncovers previously unknown cancer drivers

In three studies from the Cancer Cell Map Initiative, researchers uncovered previously unknown interactions between proteins that drive cancer and combined this new data to generate a map of protein pathways informing cancer outcomes. Their approach offers a framework that could improve scientists' understanding of cancer progression and aid in identifying therapeutic targets. For many

Study finds a significant link between statins and survival rates of triple-negative breast cancer patients

A study led by researchers from The University of Texas MD Anderson Cancer Center found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes

Public and private SARS-CoV-2 T cell receptors may be crucial for pan-coronavirus vaccines

Researchers have just established a structural basis for two spike glycoprotein epitopes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are restricted to human leukocyte antigen (HLA) A2 molecules. More specifically, they are involved in the presentation of antigenic peptides to specific T lymphocytes and recognized by public and private T cell receptors.

Large nanodiscs simulate viral entry into host cells

Membrane proteins are heavily involved in a variety of cellular processes such as signal transduction, membrane translocation, cell adhesion, and many more, and therefore are of great interest within the field of drug design. The structure of relevant membrane proteins is sometimes mimicked during research using detergent micelles, which are capable of entrapping and extracting

Stem cell treatments alleviate muscular dystrophy symptoms in compassionate-use study

Results of a compassionate-use study released in Stem Cells Translational Medicine show promising results for treating muscular dystrophies with mesenchymal stem cells (MSCs) derived from Wharton’s jelly (WJ), a substance found in the umbilical cord. Led by doctors at Klara Medical Center (KMC), Czestochowa, Poland, these WJ-MSC treatments resulted in significant improvement in several body

WEHI collaborates with Boehringer Ingelheim to develop novel anti-cancer therapeutics

WEHI has partnered with Boehringer Ingelheim, a leading research-driven pharmaceutical company, in a collaboration to discover and develop anti-cancer therapeutics using a promising new technology called targeted protein degradation. The partnership builds on more than 25 years of pioneering discoveries at WEHI, into a family of proteins known as the inhibitor of apoptosis proteins (IAPs)

Researchers unravel new mechanism that enables cancer development

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new mechanism that activates specific genes, leading to the development of cancers. They showed that a mutation that fuses two unrelated genes can promote a process similar to that observed when oil and water are

Researchers report on the role of brain cell membranes' lipids in Alzheimer's progression

Alzheimer's disease is predominant in elderly people, but the way age-related changes to lipid composition affect the regulation of biological processes is still not well understood. Links between lipid imbalance and disease have been established, in which lipid changes increase the formation of amyloid plaques, a hallmark of Alzheimer's disease. This imbalance inspired researchers from

Cell-to-cell contact helps in spreading SARS-CoV-2, finds study

People aren’t the only ones who should be social distancing — new research shows our cells need to as well. Researchers from Ohio State University in Columbus, Ohio, USA, used in-culture techniques to confirm severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission via cell-to-cell contact. While the angiotensin-converting enzyme 2 (ACE2) receptor is the entry

SARS-CoV-2 UK variant more infectious because of higher viral load

The coronavirus disease 2019 (COVID-19) pandemic was triggered by the uncontrolled spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A year and a half later, the relationship between SARS-CoV-2 viral load and infectiousness remains a matter of scientific debate. Now, a new preprint research paper posted to the bioRxiv* server aims to quantify