Tag: Cellular

Mutations in a protein known to cause Parkinson’s Disease derange transportation in and out of brain cells, reports a team of UConn Health researchers in the 27 July issue of Science Signaling. The toxic traffic jams that result eventually lead to certain brain cell death and the characteristic symptoms of Parkinson’s. “We figured out how

One of the novel coronavirus’ most insidious tricks is that it can block the ability of cells to produce protective proteins without hindering its own ability to replicate. Now, a multidisciplinary team of Yale researchers has discovered how SARS-CoV-2, the virus that causes COVID-19, accomplishes this trick by blocking production of cellular proteins, including immune

Future cardiac outcomes can be predicted by signs of cardiac stress that appear in the blood in response to exercise, Emory cardiologists report. The results were published Wed Dec 4 in JAMA Cardiology. Identifying patients with otherwise stable coronary artery disease (CAD) who are high-risk and would benefit from more intense or invasive interventions is

The cover for issue 54 of Oncotarget features Figure 2, “Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples,” by Lu, et al. The HIV-1 Tat protein is a potent activator of viral transcription. The researcher’s previous work has demonstrated that exosomal formulations of Tat can reverse HIV-1 latency in primary

For long-distance transportation within the cell, RNA molecules rely on hitchhiking. A microscopic RNA molecule might need to travel as far as a meter to get from the nucleus of a nerve cell to its tip, where it’s needed to make a protein. But exactly how RNA gets around has been “a long-standing question in

Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals. A study jointly led by Drs. Salwa Sebti and Álvaro Fernández, postdoctoral researchers in the Center for Autophagy Research, found that mice with persistently increased levels of autophagy—the process a cell uses