Tag: chronic

Tissue stiffness likely drives immune responses in many chronic diseases

Stiffness in our tissues causes tension in our cells. Research from the Buck Institute, the University Health Network (University of Toronto), Stanford University, and the University of Alberta shows that stiffness impacts the innate immune system by upping its metabolism. The findings suggest the cellular tension likely sets off an inflammatory loop that contributes to

Researchers discover inhibitor for chronic obstructive pulmonary disease

Recently, a research team led by Profs. Liu Qingsong and Liu Jing from the Institute of Health & Medical Technology of the Hefei Institutes of Physical Science (HFIPS) discovered a potent and selective PI3Kδ inhibitor IHMT-PI3Kδ-372, effective against chronic obstructive pulmonary disease (COPD) in vivo. COPD is a chronic progressive respiratory disease characterized by airflow

Hospital Outcomes Worse for Children With Chronic Kidney Disease

TUESDAY, Oct. 13, 2020 — Among children who are hospitalized, pediatric chronic kidney disease (CKD) is associated with longer length of stay (LOS) and increased costs compared with other chronic illnesses, according to a study published online Oct. 12 in the American Journal of Kidney Diseases. Zubin J. Modi, M.D., from the University of Michigan

Researchers find minimally invasive procedure to treat chronic Achilles tendon disorder

A minimally invasive procedure to treat a common foot and ankle disorder can reduce pain, recovery time, and postsurgery complications while improving functional outcomes, according to a report published in the journal Foot and Ankle Surgery. The procedure treats insertional Achilles tendinopathy, a common and chronic orthopedic disorder in which patients experience pain at the

Addressing the emotional toll of pediatric chronic conditions

Be it autism, sickle cell or other life-disrupting health conditions, being the parent of a child with a chronic condition takes a psychological toll. For too many families, however, emotional and behavioral health support has been far too difficult to obtain. Now, a project led by experts at Cincinnati Children’s reports on the progress made

Brain studies show chronic fatigue syndrome and Gulf War illness are distinct conditions

Gulf War Illness (GWI) and chronic fatigue syndrome (CFS) share symptoms of disabling fatigue, pain, systemic hyperalgesia (tenderness), negative emotion, sleep and cognitive dysfunction that are made worse after mild exertion (postexertional malaise). Now, neuroscientists at Georgetown University Medical Center have evidence, derived from human brain studies, that GWI and CFS are two distinct disorders

How chronic inflammation may drive down dopamine and motivation

Growing evidence shows that the brain’s dopamine system, which drives motivation, is directly affected by chronic, low-grade inflammation. A new paper proposes that this connection between dopamine, effort and the inflammatory response is an adaptive mechanism to help the body conserve energy. Trends in Cognitive Sciences published the theoretical framework developed by scientists at Emory

Depression, obesity and pain could be treated by targeting one protein

Depression, obesity and chronic pain could all be treated ‘by blocking the SAME protein’ Scientists blocked protein FKBP51 for the first time without also affecting others Hope will lead to treatment in humans; FKBP51 is also being tested in cancer FKBP51 has many functions from regulating glucose to stress management  e-mail 8 View comments Depression, obesity

Ovary removal may increase risk of chronic kidney disease

Premenopausal women who have their ovaries surgically removed face an increased risk of developing chronic kidney disease, according to a Mayo Clinic study published on Wednesday, Sept. 19, in the Clinical Journal of the American Society of Nephrology. “This is the first study that has shown an important link between estrogen deprivation in younger women

Chronic pain may be an important contributor to suicide

Chronic pain may be an important contributor to suicide. Nearly 9 percent of people who died by suicide in 18 states from 2003 to 2014 had documentation of chronic pain in their incident records. Findings from the National Violent Death Reporting System (NVDRS) are published in Annals of Internal Medicine. More than 25 million adults