Tag: degeneration

An oxysterol that accumulates in the eye with age can transform choroidal endothelial cells; interfering with the process might help patients with treatment-resistant age-related macular degeneration. The latest research from the laboratory of John A. Moran Eye Center physician-scientist Mary Elizabeth Hartnett, MD, reveals how an oxidized form of cholesterol can change choroidal endothelial cells

A global research team led by scientists from Singapore and the United States has discovered new evidence that there is an underlying link between degeneration of the eye and brain. They found that genetic variation at a beta-amyloid gene was significantly associated with increased risk of Primary Open Angle Glaucoma (POAG), the most common form

Increasing the levels of the anti-aging protein hormone Klotho improves the neurological deficits and prolongs life span in an experimental model with Amyotrophic Lateral Sclerosis (ALS). In addition, brain immune cells called microglia play an important role in protecting the brain against inflammation and, likely, motor neuron loss in this model. ALS or Lou Gehrig’s

Toxic protein assemblies, or “amyloids,” long considered to be key drivers in many neuromuscular diseases, also play a beneficial role in the development of healthy muscle tissue, University of Colorado Boulder researchers have found. “Ours is the first study to show that amyloid-like structures not only exist in healthy skeletal muscle during regeneration, but are

The European MACUSTAR consortium is conducting a multi-country clinical study on age-related macular degeneration (AMD) coordinated by the University of Bonn. The clinical study focuses on the intermediate stage of the disease, in which a person’s vision under low-light and low-contrast conditions is impaired. Throughout Europe, a total of 20 study centers will recruit and

A new study has shown that people who regularly eat oranges are less likely to develop macular degeneration than people who do not eat oranges. Researchers at the Westmead Institute for Medical Research interviewed more than 2,000 Australian adults aged over 50 and followed them over a 15-year period. The research showed that people who