Tag: dementia

Advancing the search for antibodies to treat Alzheimer’s disease: Two new studies shed light on the most toxic forms of amyloid-beta and how to find antibodies to target these structures

Two new studies published by investigators from Brigham and Women’s Hospital illustrate that not all forms of amyloid-beta (Aβ) protein — the protein thought to initiate Alzheimer’s disease — play an equally menacing role in the progress of the disease. Using a new way of preparing and extracting the protein as well as a new

Dr. Jekyll, Mr. Hyde: Healing mesenchymal cells morph and destroy muscles in models of spinal cord injury, ALS and spinal muscular atrophy: Targeting IL-6-STAT3 signaling in fibro-adipogenic progenitor (FAP) cells

When a muscle is acutely injured — whether through accidental strain or intentional weight lifting — special repair cells called fibro-adipogenic progenitors (FAPs) rush to the rescue. These cells coordinate the activity of the immune system and muscle stem cells to replace and repair the torn tissue. Now, scientists at Sanford Burnham Prebys Medical Discovery

Brain discovery could block aging’s terrible toll on the mind: Faulty brain plumbing to blame in Alzheimer’s, age-related memory loss — and can be fixed

Aging vessels connecting the brain and the immune system play critical roles in both Alzheimer’s disease and the decline in cognitive ability that comes with time, new research reveals. By improving the function of the lymphatic vessels, scientists at the University of Virginia School of Medicine have dramatically enhanced aged mice’s ability to learn and

Common painkillers triple harmful side effects in dementia: Commonly-prescribed opioid-based painkillers led to harmful side effects tripling in people with dementia

Commonly-prescribed opioid-based painkillers led to harmful side effects tripling in people with dementia. Researchers from the University of Exeter, King’s College London and the University of Bergen are presenting two studies at the Alzheimer’s Association International Conference 2018 (AAIC) highlighting a significant increase in harmful side effects related to the use of commonly prescribed opioid

Oxygen therapy could help combat dementia in individuals with lung disease

Breathing in additional oxygen improves the function of blood vessels in the brain of people with breathing difficulties caused by lung conditions, according to new research published in Experimental Physiology. These findings could have implications for future research aiming to prevent the development of diseases affecting the brain, such as dementia. Chronic obstructive pulmonary disease

Key molecule of aging discovered

Every cell and every organism ages sooner or later. But why is this so? Scientists at the German Cancer Research Center in Heidelberg have now discovered for the first time a protein that represents a central switching point in the aging process. It controls the life span of an individual — from the fly to

Dementia risk increased in 50-year-olds with blood pressure below hypertension threshold: Blood pressure that was higher than normal but still below the usual threshold for treating hypertension puts 50-year-olds at increased risk of dementia

New findings from the long-running Whitehall II study of over 10,000 civil servants has found 50-year-olds who had blood pressure that was higher than normal but still below the threshold commonly used when deciding to treat the condition, were at increased risk of developing dementia in later life. This increased risk was seen even when

Intellectual activities in later life may cut dementia risk

(HealthDay)—Active participation in intellectual activities among adults aged 65 years or older is associated with reduced risk of dementia, according to a study published online May 30 in JAMA Psychiatry. Allen T.C. Lee, M.B.Ch.B., from the Chinese University of Hong Kong, and colleagues conducted a longitudinal study among 15,582 community-living Chinese individuals aged 65 years

Gene linked to intellectual ability affects memory replay in mice

Researchers at the RIKEN Center for Brain Science in Japan have discovered that a gene associated with human intellectual ability is necessary for normal memory formation in mice. Published in Nature Neuroscience, the study shows that mice with only one copy of the gene replay shorter fragments of their previous experiences during periods of rest,

‘Why not take a risk’ attitude widespread among patients and providers: Belief could lead to unnecessary prescribing of antibiotics and spread of superbugs

“Antibiotics can’t hurt. They might even make me feel better. Why not take a risk?” You may have had similar thoughts when sick with the flu or common cold. Your doctor may think so too. A new study led by David Broniatowski, an assistant professor in the George Washington University’s department of engineering management and

E. coli infection induces delirium in aging rats: Research could inform understanding of how immune system activation affects cognitive function in the elderly

Activation of the immune system by an infection may temporarily disrupt formation of long-term memories in healthy, aging rats by reducing levels of a protein required for brain cells to make new connections, suggests new research published in eNeuro. Cognitive decline in old age is thought to be gradual, as in Alzheimer’s disease. However, an

Study reveals gaps in follow-up care after concussion

Being discharged from a hospital trauma center after receiving treatment for a traumatic brain injury (TBI) does not necessarily mean that a patient has fully recovered. TBI can lead to long-lasting physical and cognitive symptoms, but a new study in JAMA Network Open suggests that many patients may not be receiving follow-up care. Patients in