Heart attack is a leading cause of death worldwide and new treatment strategies are highly sought-after. Unfortunately lasting damage to the heart muscle is not uncommon following such an event. Published in Redox Biology, the pre-clinical study sheds new light on the potential of the acute therapy with ?-TOH (vitamin E) in patients presenting with
Researchers at the Paul Scherrer Institute PSI in Villigen, Switzerland, have for the first time elucidated the structure of important enzymes in human cells that alter essential building blocks of the cellular cytoskeleton. This reveals the missing part of a cycle that regulates the build-up or breakdown of supporting elements of the cell. The enzymes
Consumption of dietary supplements sold for weight loss, muscle building, and energy was associated with increased risk for severe medical events in children and young adults compared to consumption of vitamins, according to new research led by Harvard T.H. Chan School of Public Health. The study found that, compared with vitamins, these types of supplements
Accumulation of fat in the liver, known as fatty liver disease, is experienced by over 5.5 million Australians, including more than 40% of all adults over the age of 50. Fatty liver develops from a combination of both genetic and environmental causes, which influence the age of onset and severity of the disease. Experts are
Almost half of all Americans take a vitamin supplement, and yet many large-scale, placebo-controlled clinical trials of various supplements have found little or no benefit. A new study led by investigators from Brigham and Women’s Hospital suggests an intriguing reason for this: genetic variation may be influencing these effects, increasing risk in some individuals while
The venom of insects such as wasps and bees is full of compounds that can kill bacteria. Unfortunately, many of these compounds are also toxic for humans, making it impossible to use them as antibiotic drugs. After performing a systematic study of the antimicrobial properties of a toxin normally found in a South American wasp,
A University of Adelaide forensic pathologist is warning that potentially harmful substances found in herbal medicines may be playing a bigger role in deaths of ‘health tourists’ than previously thought. Professor Roger Byard is calling for closer checks during post-mortems for the presence of drugs and adulterants that originate from herbal remedies. “There is a
Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for a therapeutic action of an ancient herbal medicine used across Africa to treat various illnesses, including epilepsy. The herbal medicine, a leaf extract from the shrub Mallotus oppositifolius, was previously found to
Consuming too much vitamin A may decrease bone thickness, leading to weak and fracture prone bones, according to a study published in the Journal of Endocrinology. The study, undertaken in mice, found that sustained intake of vitamin A, at levels equivalent to 4.5-13 times the human recommended daily allowance (RDA), caused significant weakening of the
Powdered protein supplements are one of the most commonly consumed nutritional supplements, whether by professional athletes or amateurs, even by those who use them for aesthetic purposes instead of sporting ones. This study, led by a researcher from the Area of Human Motility and Sporting Performance at the University of Seville, has analysed the quality
Decades after scientists discovered hundreds of different fatty acids in vegetable oils, two that had managed to elude detection have finally revealed themselves to a team led by the University of Nebraska-Lincoln and Huazhong Agricultural University in China. Named for the sites of the two leading institutions, Nebraskanic acid and Wuhanic acid make up nearly
Pregnant women who had low plasma levels of long chain n-3 fatty acids in their first and second trimesters were at a significantly higher risk of early preterm birth when compared with women who had higher levels of these fatty acids, according to new research from Harvard T.H. Chan School of Public Health in collaboration
University of Leicester researchers have shed new light on how bacteria sense nutrients in their environment — a finding that could provide important knowledge in the development of drugs and antibiotics to combat a range of diseases including tuberculosis. The research team, led by Dr Helen O’Hare from the University of Leicester’s Department of Infection,
The importance of the human brown adipose tissue (BAT) has become clearer during the past ten years. Using positron emission tomography, PET, it was shown that adult humans have functional BAT. Coldness is an effective activator of the BAT metabolic function but, in rodents, eating has the same effect. Now, the researchers at Turku PET
There is a link between higher serum vitamin D levels and lower plasma cholesterol levels in primary school children, new research from the University of Eastern Finland shows. Children whose serum 25-hydroxyvitamin D levels exceeded 80 nmol/l had lower plasma total and low-density lipoprotein (LDL) cholesterol levels than children whose serum 25-hydroxyvitamin D levels were
Higher levels of belly fat are associated with lower vitamin D levels in obese individuals, according to data presented in Barcelona at the European Society of Endocrinology annual meeting, ECE 2018. The study reports that vitamin D levels are lower in individuals with higher levels of belly fat, and suggests that individuals, particularly the overweight
Scientists at the University of Kent have made a significant discovery about how the vitamin content of some plants can be improved to make vegetarian and vegan diets more complete. Vitamin B12 (known as cobalamin) is an essential dietary component but vegetarians are more prone to B12 deficiency as plants neither make nor require this
The passage of ions through the cell membrane is controlled by ion channels, which are protein complexes that regulate vital processes, such as the heartbeat, as well as being the target towards which many drugs are directed. Now a study by the University of Wisconsin, led by a Spanish researcher, presents a novel model to
Peptides are short chains of amino acids that can bind to proteins and change their function. They show high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occurring peptides such as insulin, oxytocin, somatostatin and the antibiotics vancomycin or polymyxin
The longevity and health improvements seen in animals on sulfur amino acid-restricted diets could translate to people, according to Penn State College of Medicine researchers who recently conducted a review of published studies. More research is needed to confirm the benefits in people, the scientists said. Amino acids are the building blocks of all proteins
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