Tag: expression

Type 1 diabetes (T1D) is an autoimmune disease in which a misdirected immune system gradually destroys healthy pancreatic islet β cells, resulting in a lack of insulin. The exact cause of T1D remains unknown. However, β cell-reactive autoantibodies can be detected in circulating blood months to years before diagnosis, raising the possibility of intervening to

A new technique could dramatically reduce the number of colorectal cancer patients who unnecessarily undergo major surgery to remove tumors, instead of a minimally invasive procedure. Biomedical scientist Xin Wang of City University of Hong Kong and colleagues have used machine learning to identify a gene expression pattern, or signature, associated with colorectal cancer spreading,

The cover for issue 54 of Oncotarget features Figure 2, “Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples,” by Lu, et al. The HIV-1 Tat protein is a potent activator of viral transcription. The researcher’s previous work has demonstrated that exosomal formulations of Tat can reverse HIV-1 latency in primary

The abnormal expression of many genes that have previously been associated with autism are also present in cases of violent psychopathy, a new study shows. The researchers used stem cell technology to analyze the expression of genes and proteins in the brain cells of psychopathic violent offenders. Published in Molecular Psychiatry, the findings may open

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology. People with rheumatoid arthritis often receive medications that target and inhibit Tumor-Necrosis Factor (TNF), a