Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals. A study jointly led by Drs. Salwa Sebti and Álvaro Fernández, postdoctoral researchers in the Center for Autophagy Research, found that mice with persistently increased levels of autophagy—the process a cell uses
Prion diseases are slow degenerative brain diseases that occur in people and various other mammals. No vaccines or treatments are available, and these diseases are almost always fatal. Scientists have found little evidence of a protective immune response to prion infections. Further, microglia—brain cells usually involved in the first level of host defense against infections
University of Minnesota researchers in the dentistry school-based Institute for Molecular Virology (IMV) have made a key discovery that could have important implications for developing a strategy to stop the spread of a highly infectious virus currently spreading among remote areas of central Australia. Called human T-cell leukemia virus type 1 (HTLV-1), infection rates are
During a stroke or an epileptic seizure, neurons in affected parts of the brain fire at an abnormally rapid rate. One byproduct of this condition is that the pH of the brain drops markedly, rendering the local environment inhospitably acidic. Using a powerful microscopy method called cryo-EM, biologists at Cold Spring Harbor Laboratory (CSHL) have
Advances in our understanding of the development and persistence of Obsessive-Compulsive Disorder (OCD) have the potential to improve treatment according to a new study by the University of Waterloo. The study found that fear of guilt evokes feelings of doubt in decision-making, with greater fear of guilt being associated with greater self-reported difficulty making decisions,
Interruptions in workflow, such as a phone call while working on another task, or when a colleague stops by for a chat, can lead to inefficiencies in the workplace. For nurses working in emergency departments, those interruptions could affect patient care. Now, a study from the University of Missouri has determined that workflow interruptions are
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