When an embryo develops, a wide variety of proteins and enzymes trigger a series of biochemical reactions. The development of the lymphatic vasculature is crucially dependent on one specific protein—the growth factor VEGF-C. In order to become biologically active and to initiate downstream signaling events, the protein must first undergo processing steps. Thus far it
The search by scientists to find ways to combat obesity continues. Recently, investigators have been exploring whether they can engage the lymphatic system to help regulate obesity-induced inflammation of fat (adipose) tissue and restore systemic metabolic fitness. In a study appearing in he American Journal of Pathology, researchers report that augmenting lymphatic vessel formation in
To ensure elimination of the Wuchereria bancrofti, a parasitic roundworm that causes lymphatic filariasis, public health workers must follow up mass drug administration with careful monitoring for recurrence. To that end, a study published this week in PLOS Neglected Tropical Diseases analyzes the effectiveness of mosquito screening as a tool to gauge parasite presence. The
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