The fight against cystic fibrosis (CF) has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones. The research published in the journal Stem Cell Research and Therapy applies cell transplantation therapy, normally used in bone marrow
A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma, finds a new study led by UCL and Imperial College London researchers. In the new Scientific Reports paper, the researchers report a new method to deliver curcumin, extracted from the yellow spice turmeric, directly to the back of
A City of Hope scientist has discovered a gene-editing technology that could efficiently and accurately correct the genetic defects that underlie certain diseases, positioning the new tool as the basis for the next generation of genetic therapies. This editing platform, discovered by City of Hope’s Saswati Chatterjee, Ph.D., eventually may be used to cure inherited
Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute have developed a new bone engineering technique called Segmental Additive Tissue Engineering (SATE). The technique, described in a paper published online today in Scientific Reports, allows researchers to combine segments of bone engineered from stem cells to create large scale, personalized grafts that will
Many people view the Tibetan Plateau, or “Roof of the World,” as a pristine alpine environment, largely untouched by pollution. But researchers, reporting in ACS’ journal Environmental Science & Technology, have now shown that traditional Tibetan medicine (TTM) exposes people and the environment to high levels of mercury and methylmercury. Used by Tibetans for more
A scientific consortium led by Dr. Eleanor Scerri, British Academy Postdoctoral Fellow at the University of Oxford and researcher at the Max Planck Institute for the Science of Human History, has found that human ancestors were scattered across Africa, and largely kept apart by a combination of diverse habitats and shifting environmental boundaries, such as
Scientists have just identified a class of ‘danger signals’ that are highly efficient at triggering an immune response in infants and newborns. They believe their discovery may have the potential to reduce both the age of vaccine administration and the need for multiple booster injections in infants and newborns, whose immune systems operate differently to
A research team found a novel function of fibroblast growth factor 2 (FGF2), a self-renewal factor for spermatogonial stem cell (SSC) which is the origin of the sperm production. Although it has demonstrated that both FGF2 and glial cell line-derived neurotrophic factor (GDNF) is indispensable for SSC self-renewal and survival in vitro, the present study
The human body is an extremely complex molecular machine, the details of which can be followed through certain substances; so-called biomarkers. Unfortunately, it is not yet possible to monitor biomarkers live in patients when these are present in minuscule concentrations. Researchers at Eindhoven University of Technology have now developed a new technique that can become
How are chromosomes arranged in the cell nucleus? Is it possible that they communicate with one another by “touching” each other? To answer this question and to shed more light on the fundamental properties of the communication between different chromosomes, Philipp Maass from Friedrich Luft’s lab at the Max Delbrück Center for Molecular Medicine in
Electronic textiles could allow a person to control household appliances or computers from a distance simply by touching a wristband or other item of clothing — something that could be particularly helpful for those with limited mobility. Now researchers, reporting in ACS Nano, have developed a new type of e-textile that is self-powered, highly sensitive
The internal clock controls all vital functions in the body. Body temperature as well as blood pressure or the release of certain enzymes are subject to oscillations throughout the day, the so-called circadian rhythm. For the first time, a team around Professor Oliver Söhnlein has now shown the influence of circadian rhythms on atherosclerosis —
Millions of neurons in the gastrointestinal tract coordinate their activity to generate the muscle contractions that propel waste through the last leg of the digestive system, according to a study of isolated mouse colons published in JNeurosci. The newly identified neuronal firing pattern may represent an early feature preserved through the evolution of nervous systems.
A new study conducted by the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that there were more than 156,000 calls to US Poison Control Centers regarding exposures to attention-deficit hyperactivity disorder (ADHD) medications among children and adolescents 19 years of age and younger from January
Numerous bat species hunt and migrate at great altitudes. Yet the open sky had, until recently, not been on the radar of conservation scientists as a habitat relevant to a large variety of species. Christian Voigt and colleagues from the Leibniz Institute for Zoo and Wildlife Research (IZW) in Berlin have collated the current scientific
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. This is the first time researchers have successfully applied CRISPR technology to a type of inherited disease known as a dominant disorder. This same tool
Erythropoietin (EPO) helps to protect and repair vulnerable brains though it remains a mystery how the anemia drug does so. Genetic analyses conducted by a multi-institutional research team finds that EPO may work its neuroprotective magic by modifying genes essential for regulating growth and development of nervous tissue as well as genes that respond to
Researchers from Ben-Gurion University of the Negev (BGU) in Beer-Sheva, Israel have demonstrated for the first time the feasibility of a robotic system that plays Tic Tac Toe with rehabilitation patients to improve real-life task performance. The interdisciplinary research team designed a game with a robotic arm to simulate “3D Functional Activities of Daily Living”
A new JBMR Plus review examines the negative impacts of weight loss surgery on bone health. The review of published studies notes that weight loss surgery can cause declines in bone mass and strength, and it is linked with an increased risk of bone fractures. Skeletal changes after surgery appear early and continue even after
About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect — they induce the bone loss called osteoporosis, causing an estimated yearly bone fracture rate of 5 percent. An alternative treatment option now appears promising, according to results of
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