Tag: metastasis

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing

Science is collaborative by nature, since scientific knowledge only advances, step by step, through combined efforts and findings. Nevertheless, there is often a lack of communication regarding the more technical and everyday advances in laboratory work, and as a result, research progresses less quickly. In recent years, the development of the digital ecosystem has resulted

Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step toward the development of an agent against the metastasis of certain cancers. Using the Swiss Light Source, they deciphered the structure of a receptor that plays a crucial role in the migration of

Scientists at VCU Massey Cancer Center have identified key biological pathways that regulate the spread of tumor cells to vital organs. These findings may have a significant influence on the development of new therapies that slow or prevent breast cancer metastasis. Metastasis refers to the spread of cancer cells to other organs, and the likelihood

The concept of survival of the fittest most often applies to the competition that occurs within and between animal species, but evolutionary pressures can be found elsewhere—even in a cancerous tumor. Cancer researchers have come to understand tumors not as lumps of identical cells, but rather as diverse, dynamic populations unto themselves. And, like individuals

Scientists have long theorized that blood flow plays an integral role in cancer metastasis. But new research testing this long-held hypothesis in zebrafish and humans confirms that the circulatory blood flow impacts the position where circulating tumor cells ultimately arrest in the vasculature and exit into the body, where they can form a metastasis. In